YES1

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
File:PBB Protein YES1 image.jpg PDB rendering based on 2hda.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2hda​, 2hwo​, 2hwp​, 2oiq​
Identifiers
Symbols	YES1 ; HsT441; P61-YES; Yes; c-yes
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55900
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE YES1 202933 s at tn.png
File:PBB GE YES1 202932 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1, also known as YES1, is a human gene.

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.

Further reading

• Brickell PM (1992). "The p60c-src family of protein-tyrosine kinases: structure, regulation, and function". Critical reviews in oncogenesis. 3 (4): 401–46. PMID 1384720.
• Toyoshima K, Semba K, Nishizawa M; et al. (1988). "Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family". Int. Symp. Princess Takamatsu Cancer Res. Fund. 17: 11–20. PMID 3332005.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sudol M, Chen HI, Bougeret C; et al. (1995). "Characterization of a novel protein-binding module--the WW domain". FEBS Lett. 369 (1): 67–71. PMID 7641887.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Summy JM, Sudol M, Eck MJ; et al. (2004). "Specificity in signaling by c-Yes". Front. Biosci. 8: s185–205. PMID 12456296.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cichowski K, McCormick F, Brugge JS (1992). "p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets". J. Biol. Chem. 267 (8): 5025–8. PMID 1544885.CS1 maint: Multiple names: authors list (link)
• Huang MM, Bolen JB, Barnwell JW; et al. (1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. PMID 1715582.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H (1992). "Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10411–5. PMID 1720539.CS1 maint: Multiple names: authors list (link)
• Krueger J, Zhao YH, Murphy D, Sudol M (1991). "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis". Oncogene. 6 (6): 933–40. PMID 2067846.CS1 maint: Multiple names: authors list (link)
• Zhao YH, Krueger JG, Sudol M (1991). "Expression of cellular-yes protein in mammalian tissues". Oncogene. 5 (11): 1629–35. PMID 2267131.CS1 maint: Multiple names: authors list (link)
• Sukegawa J, Semba K, Yamanashi Y; et al. (1987). "Characterization of cDNA clones for the human c-yes gene". Mol. Cell. Biol. 7 (1): 41–7. PMID 2436037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Semba K, Yamanashi Y, Nishizawa M; et al. (1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. PMID 2983418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bull HA, Brickell PM, Dowd PM (1994). "Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells". FEBS Lett. 351 (1): 41–4. PMID 7521304.CS1 maint: Multiple names: authors list (link)
• Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495.CS1 maint: Multiple names: authors list (link)
• Courtneidge SA, Dhand R, Pilat D; et al. (1993). "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor". EMBO J. 12 (3): 943–50. PMID 7681396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mori S, Rönnstrand L, Yokote K; et al. (1993). "Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases". EMBO J. 12 (6): 2257–64. PMID 7685273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waltenberger J, Claesson-Welsh L, Siegbahn A; et al. (1994). "Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor". J. Biol. Chem. 269 (43): 26988–95. PMID 7929439.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Silverman GA, Kuo WL, Taillon-Miller P, Gray JW (1993). "Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18". Genomics. 15 (2): 442–5. doi:10.1006/geno.1993.1086. PMID 8449516.CS1 maint: Multiple names: authors list (link)