MAPRE2
| Microtubule-associated protein, RP/EB family, member 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | MAPRE2 ; RP1; EB1; EB2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 75027 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MAPRE2 202501 at tn.png | |||||||||||
| File:PBB GE MAPRE2 213489 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Microtubule-associated protein, RP/EB family, member 2, also known as MAPRE2, is a human gene.[1]
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.[1]
References
Further reading
- Tirnauer JS, Bierer BE (2000). "EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability". J. Cell Biol. 149 (4): 761–6. PMID 10811817.
- Su LK, Burrell M, Hill DE; et al. (1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712.
- Renner C, Pfitzenmeier JP, Gerlach K; et al. (1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J. Immunol. 159 (3): 1276–83. PMID 9233623.
- Berrueta L, Kraeft SK, Tirnauer JS; et al. (1998). "The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10596–601. PMID 9724749.
- Morrison EE, Wardleworth BN, Askham JM; et al. (1999). "EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle". Oncogene. 17 (26): 3471–7. doi:10.1038/sj.onc.1202247. PMID 10030671.
- Juwana JP, Henderikx P, Mischo A; et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. PMID 10188731.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Nakamura M, Zhou XZ, Lu KP (2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. PMID 11470413.
- Askham JM, Vaughan KT, Goodson HV, Morrison EE (2003). "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMID 12388762.
- Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (2003). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol. Biol. Cell. 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMID 12475954.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Rush J, Moritz A, Lee KA; et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Mimori-Kiyosue Y, Grigoriev I, Lansbergen G; et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMID 15631994.
- Xu H, Hebert MD (2006). "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin". BMC Cell Biol. 6 (1): 23. doi:10.1186/1471-2121-6-23. PMID 15862129.
- Wang Y, Zhou X, Zhu H; et al. (2005). "Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway". Oncogene. 24 (44): 6637–45. doi:10.1038/sj.onc.1208819. PMID 16007168.
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