KLK1

Kallikrein 1
File:PBB Protein KLK1 image.jpg PDB rendering based on 1spj.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1spj​
Identifiers
Symbols	KLK1 ; KLKR; Klk6; hK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 88436
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE KLK1 216699 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kallikrein 1, also known as KLK1, is a human gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.

Further reading

• Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions". Biol. Chem. 382 (1): 5–14. PMID 11258672.CS1 maint: Multiple names: authors list (link)
• Lottspeich F, Geiger R, Henschen A, Kutzbach C (1980). "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1947–50. PMID 393608.CS1 maint: Multiple names: authors list (link)
• Riegman PH, Vlietstra RJ, Suurmeijer L; et al. (1992). "Characterization of the human kallikrein locus". Genomics. 14 (1): 6–11. PMID 1385301.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Richards RI, Holman K, Shen Y; et al. (1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics. 11 (1): 77–82. PMID 1684954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henttu P, Lukkarinen O, Vihko P (1990). "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate". Int. J. Cancer. 45 (4): 654–60. PMID 1691151.CS1 maint: Multiple names: authors list (link)
• Qin H, Kemp J, Yip MY; et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Hum. Hered. 41 (4): 222–6. PMID 1783409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu HS, Lin FK, Chao L, Chao J (1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation". Int. J. Pept. Protein Res. 33 (4): 237–49. PMID 2666327.CS1 maint: Multiple names: authors list (link)
• Angermann A, Bergmann C, Appelhans H (1990). "Cloning and expression of human salivary-gland kallikrein in Escherichia coli". Biochem. J. 262 (3): 787–93. PMID 2686621.CS1 maint: Multiple names: authors list (link)
• Evans BA, Yun ZX, Close JA; et al. (1988). "Structure and chromosomal localization of the human renal kallikrein gene". Biochemistry. 27 (9): 3124–9. PMID 2898948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukushima D, Kitamura N, Nakanishi S (1986). "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein". Biochemistry. 24 (27): 8037–43. PMID 3004571.CS1 maint: Multiple names: authors list (link)
• Kellermann J, Lottspeich F, Geiger R, Deutzmann R (1988). "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites". Protein Seq. Data Anal. 1 (3): 177–82. PMID 3163150.CS1 maint: Multiple names: authors list (link)
• Takahashi S, Irie A, Katayama Y; et al. (1986). "N-terminal amino acid sequence of human urinary prokallikrein". J. Biochem. 99 (3): 989–92. PMID 3635530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baker AR, Shine J (1986). "Human kidney kallikrein: cDNA cloning and sequence analysis". DNA. 4 (6): 445–50. PMID 3853975.
• Del Nery E, Chagas JR, Juliano MA; et al. (1996). "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments". Biochem. J. 312 ( Pt 1): 233–8. PMID 7492318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen LM, Richards GP, Chao L, Chao J (1995). "Molecular cloning, purification and in situ localization of human colon kallikrein". Biochem. J. 307 ( Pt 2): 481–6. PMID 7733886.CS1 maint: Multiple names: authors list (link)
• Clements J, Mukhtar A, Ehrlich A, Yap B (1995). "Glandular kallikrein gene expression in the human uterus". Braz. J. Med. Biol. Res. 27 (8): 1855–63. PMID 7749374.CS1 maint: Multiple names: authors list (link)
• Lin FK, Lin CH, Chou CC; et al. (1993). "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes". Biochim. Biophys. Acta. 1173 (3): 325–8. PMID 7916636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gomes RA, Juliano L, Chagas JR, Hial V (1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney". Can. J. Physiol. Pharmacol. 75 (6): 757–61. PMID 9276160.CS1 maint: Multiple names: authors list (link)
• Bourgeois L, Brillard-Bourdet M, Deperthes D; et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". J. Biol. Chem. 272 (47): 29590–5. PMID 9368023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochim. Biophys. Acta. 1479 (1–2): 237–46. PMID 10862973.CS1 maint: Multiple names: authors list (link)