KLK6

Kallikrein-related peptidase 6
File:PBB Protein KLK6 image.jpg PDB rendering based on 1gvl.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gvl​, 1l2e​, 1lo6​
Identifiers
Symbols	KLK6 ; ZYME; Bssp; Klk7; MGC9355; NEUROSIN; PRSS18; PRSS9; SP59; hK6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68279
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KLK6 204733 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kallikrein-related peptidase 6, also known as KLK6, is a human gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

Further reading

• Yousef GM, Kishi T, Diamandis EP (2003). "Role of kallikrein enzymes in the central nervous system". Clin. Chim. Acta. 329 (1–2): 1–8. PMID 12589961.CS1 maint: Multiple names: authors list (link)
• Anisowicz A, Sotiropoulou G, Stenman G; et al. (1997). "A novel protease homolog differentially expressed in breast and ovarian cancer". Mol. Med. 2 (5): 624–36. PMID 8898378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamashiro K, Tsuruoka N, Kodama S; et al. (1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain". Biochim. Biophys. Acta. 1350 (1): 11–4. PMID 9003450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Little SP, Dixon EP, Norris F; et al. (1997). "Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain". J. Biol. Chem. 272 (40): 25135–42. PMID 9312124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousef GM, Luo LY, Scherer SW; et al. (2000). "Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease". Genomics. 62 (2): 251–9. doi:10.1006/geno.1999.6012. PMID 10610719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gan L, Lee I, Smith R; et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petraki CD, Karavana VN, Skoufogiannis PT; et al. (2001). "The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry". J. Histochem. Cytochem. 49 (11): 1431–41. PMID 11668196.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernett MJ, Blaber SI, Scarisbrick IA; et al. (2002). "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system". J. Biol. Chem. 277 (27): 24562–70. doi:10.1074/jbc.M202392200. PMID 11983703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gomis-Rüth FX, Bayés A, Sotiropoulou G; et al. (2002). "The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family". J. Biol. Chem. 277 (30): 27273–81. doi:10.1074/jbc.M201534200. PMID 12016211.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scarisbrick IA, Blaber SI, Lucchinetti CF; et al. (2002). "Activity of a newly identified serine protease in CNS demyelination". Brain. 125 (Pt 6): 1283–96. PMID 12023317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zarghooni M, Soosaipillai A, Grass L; et al. (2002). "Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients". Clin. Biochem. 35 (3): 225–31. PMID 12074831.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoffman BR, Katsaros D, Scorilas A; et al. (2002). "Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker". Br. J. Cancer. 87 (7): 763–71. doi:10.1038/sj.bjc.6600533. PMID 12232761.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitsui S, Okui A, Uemura H; et al. (2003). "Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease". Ann. N. Y. Acad. Sci. 977: 216–23. PMID 12480753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hutchinson S, Luo LY, Yousef GM; et al. (2003). "Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin". Clin. Chem. 49 (5): 746–51. PMID 12709365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magklara A, Mellati AA, Wasney GA; et al. (2003). "Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors". Biochem. Biophys. Res. Commun. 307 (4): 948–55. PMID 12878203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwata A, Maruyama M, Akagi T; et al. (2004). "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies". Hum. Mol. Genet. 12 (20): 2625–35. doi:10.1093/hmg/ddg283. PMID 12928483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sauter ER, Lininger J, Magklara A; et al. (2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk". Int. J. Cancer. 108 (4): 588–91. doi:10.1002/ijc.11607. PMID 14696124.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G (2004). "Cloning and characterization of novel isoforms of the human kallikrein 6 gene". Biochem. Biophys. Res. Commun. 320 (1): 54–61. doi:10.1016/j.bbrc.2004.04.205. PMID 15207701.CS1 maint: Multiple names: authors list (link)