PPAN
Peter pan homolog (Drosophila) | |||||||||
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Identifiers | |||||||||
Symbols | PPAN ; BXDC3; MGC14226; MGC45852; SSF; SSF1; SSF2 | ||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 5690 | ||||||||
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Orthologs | |||||||||
Template:GNF Ortholog box | |||||||||
Species | Human | Mouse | |||||||
Entrez | n/a | n/a | |||||||
Ensembl | n/a | n/a | |||||||
UniProt | n/a | n/a | |||||||
RefSeq (mRNA) | n/a | n/a | |||||||
RefSeq (protein) | n/a | n/a | |||||||
Location (UCSC) | n/a | n/a | |||||||
PubMed search | n/a | n/a |
Peter pan homolog (Drosophila), also known as PPAN, is a human gene.[1]
The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. This gene was found to cotranscript with P2RY11/P2Y(11), an immediate downstream gene on the chromosome that encodes an ATP receptor. The chimeric transcripts of this gene and P2RY11 were found to be ubiquitously present and regulated during granulocytic differentiation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells.[1]
References
Further reading
- Communi D, Govaerts C, Parmentier M, Boeynaems JM (1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J. Biol. Chem. 272 (51): 31969–73. PMID 9405388.
- Migeon JC, Garfinkel MS, Edgar BA (1999). "Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth". Mol. Biol. Cell. 10 (6): 1733–44. PMID 10359593.
- Welch PJ, Marcusson EG, Li QX; et al. (2000). "Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes". Genomics. 66 (3): 274–83. doi:10.1006/geno.2000.6230. PMID 10873382.
- Suarez-Huerta N, Boeynaems JM, Communi D (2000). "Cloning, genomic organization, and tissue distribution of human Ssf-1". Biochem. Biophys. Res. Commun. 275 (1): 37–42. doi:10.1006/bbrc.2000.3259. PMID 10944437.
- Communi D, Suarez-Huerta N, Dussossoy D; et al. (2001). "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes". J. Biol. Chem. 276 (19): 16561–6. doi:10.1074/jbc. M009609200 Check
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value (help). PMID 11278528. - Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.
- Duhant X, Schandené L, Bruyns C; et al. (2002). "Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes". J. Immunol. 169 (1): 15–21. PMID 12077223.
- Scherl A, Couté Y, Déon C; et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc. E02-05-0271 Check
|doi=
value (help). PMID 12429849. - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
- Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
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