SYMPK

Symplekin
Identifiers
Symbols	SYMPK ; FLJ27092; SPK; SYM
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37969
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SYMPK 32402 s at tn.png
File:PBB GE SYMPK 202339 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Symplekin, also known as SYMPK, is a human gene.

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.

Further reading

• Keon BH, Schäfer S, Kuhn C; et al. (1996). "Symplekin, a novel type of tight junction plaque protein". J. Cell Biol. 134 (4): 1003–18. PMID 8769423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ueki K, Ramaswamy S, Billings SJ; et al. (1997). "Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene". Somat. Cell Mol. Genet. 23 (3): 229–31. PMID 9330635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alwazzan M, Hamshere MG, Lennon GG, Brook JD (1998). "Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat". Mamm. Genome. 9 (6): 485–7. PMID 9585442.CS1 maint: Multiple names: authors list (link)
• Faber PW, Barnes GT, Srinidhi J; et al. (1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. 7 (9): 1463–74. PMID 9700202.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paffenholz R, Kuhn C, Grund C; et al. (1999). "The arm-repeat protein NPRAP (neurojungin) is a constituent of the plaques of the outer limiting zone in the retina, defining a novel type of adhering junction". Exp. Cell Res. 250 (2): 452–64. doi:10.1006/excr.1999.4534. PMID 10413599.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. PMID 10669729.
• Venter JC, Adams MD, Myers EW; et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Langbein L, Pape UF, Grund C; et al. (2004). "Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas". Eur. J. Cell Biol. 82 (8): 385–400. PMID 14533737.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xing H, Mayhew CN, Cullen KE; et al. (2004). "HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin". J. Biol. Chem. 279 (11): 10551–5. doi:10.1074/jbc.M311719200. PMID 14707147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barnard DC, Ryan K, Manley JL, Richter JD (2005). "Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation". Cell. 119 (5): 641–51. doi:10.1016/j.cell.2004.10.029. PMID 15550246.CS1 maint: Multiple names: authors list (link)
• Kolev NG, Steitz JA (2006). "Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs". Genes Dev. 19 (21): 2583–92. doi:10.1101/gad.1371105. PMID 16230528.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kavanagh E, Buchert M, Tsapara A; et al. (2007). "Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin". J. Cell. Sci. 119 (Pt 24): 5098–105. doi:10.1242/jcs.03297. PMID 17158914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)