PPP1R14A

Protein phosphatase 1, regulatory (inhibitor) subunit 14A
Identifiers
Symbols	PPP1R14A ; CPI-17; PPP1INL
External IDs	Template:OMIM5 Template:MGI HomoloGene: 12267
Gene ontology Molecular function Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Protein phosphatase 1, regulatory (inhibitor) subunit 14A, also known as PPP1R14A, is a human gene.

PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase (see MIM 603768). Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration.[supplied by OMIM]

Further reading

• Eto M, Ohmori T, Suzuki M; et al. (1996). "A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization". J. Biochem. 118 (6): 1104–7. PMID 8720121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eto M, Senba S, Morita F, Yazawa M (1997). "Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle". FEBS Lett. 410 (2–3): 356–60. PMID 9237662.CS1 maint: Multiple names: authors list (link)
• Koyama M, Ito M, Feng J; et al. (2000). "Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase". FEBS Lett. 475 (3): 197–200. PMID 10869555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamaguchi T, Ito M, Feng J; et al. (2000). "Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N.". Biochem. Biophys. Res. Commun. 274 (3): 825–30. doi:10.1006/bbrc.2000.3225. PMID 10924361.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamawaki K, Ito M, Machida H; et al. (2001). "Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase". Biochem. Biophys. Res. Commun. 285 (4): 1040–5. doi:10.1006/bbrc.2001.5290. PMID 11467857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Z, Yu L, Zhang Y; et al. (2002). "Identification of human, mouse and rat PPP1R14A, protein phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to chromosome 19q13.13-q13.2". Mol. Biol. Rep. 28 (2): 91–101. PMID 11931393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Lett. 517 (1–3): 167–71. PMID 12062430.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu QR, Zhang PW, Lin Z; et al. (2004). "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA". Biochem. J. 377 (Pt 1): 171–81. doi:10.1042/BJ20030128. PMID 12974676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zemlickova E, Johannes FJ, Aitken A, Dubois T (2004). "Association of CPI-17 with protein kinase C and casein kinase I.". Biochem. Biophys. Res. Commun. 316 (1): 39–47. doi:10.1016/j.bbrc.2004.02.014. PMID 15003508.CS1 maint: Multiple names: authors list (link)
• Kolosova IA, Ma SF, Adyshev DM; et al. (2004). "Role of CPI-17 in the regulation of endothelial cytoskeleton". Am. J. Physiol. Lung Cell Mol. Physiol. 287 (5): L970–80. doi:10.1152/ajplung.00398.2003. PMID 15234908.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin H, Sperka T, Herrlich P, Morrison H (2006). "Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase". Nature. 442 (7102): 576–9. doi:10.1038/nature04856. PMID 16885985.CS1 maint: Multiple names: authors list (link)
• Morin C, Sirois M, Echave V; et al. (2007). "Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi". Am. J. Respir. Cell Mol. Biol. 36 (5): 633–41. doi:10.1165/rcmb.2006-0281OC. PMID 17237191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lartey J, Smith M, Pawade J; et al. (2007). "Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor". Biol. Reprod. 76 (6): 971–82. doi:10.1095/biolreprod.106.058982. PMID 17301291.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)