P53 upregulated modulator of apoptosis
Template:Protbox The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.
See also
- Apoptosis
- Apoptosome
- Bcl-2
- Bcl-2-associated_X_protein (BAX)
- BH3 interacting domain death agonist (BID)
- Caspases
- Cytochrome c
- Noxa
- Mitochondrion
References
- ↑
Nakano, K. (2001). "PUMA, a Novel Proaptotic Gene, is Induced by p53". Molecular Cell. 7: 683–694. Unknown parameter
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