TOP1
Topoisomerase (DNA) I | |||||||||||||
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File:PBB Protein TOP1 image.jpg PDB rendering based on 1a31. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | TOP1 ; TOPI | ||||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 2467 | ||||||||||||
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Orthologs | |||||||||||||
Template:GNF Ortholog box | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | n/a | n/a | |||||||||||
Ensembl | n/a | n/a | |||||||||||
UniProt | n/a | n/a | |||||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||||
RefSeq (protein) | n/a | n/a | |||||||||||
Location (UCSC) | n/a | n/a | |||||||||||
PubMed search | n/a | n/a |
Topoisomerase (DNA) I, also known as TOP1, is a human gene.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.[1]
See also
References
Further reading
- Friedberg EC (1996). "Relationships between DNA repair and transcription". Annu. Rev. Biochem. 65: 15–42. doi:10.1146/annurev.bi.65.070196.000311. PMID 8811173.
- Leppard JB, Champoux JJ (2005). "Human DNA topoisomerase I: relaxation, roles, and damage control". Chromosoma. 114 (2): 75–85. doi:10.1007/s00412-005-0345-5. PMID 15830206.
This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it. |