WFDC2

WAP four-disulfide core domain 2
Identifiers
Symbols	WFDC2 ; HE4; MGC57529; WAP5; dJ461P17.6
External IDs	Template:MGI HomoloGene: 4450
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WFDC2 203892 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WAP four-disulfide core domain 2, also known as WFDC2, is a human gene.

This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.

Further reading

• Kirchhoff C (1998). "Molecular characterization of epididymal proteins". Rev. Reprod. 3 (2): 86–95. PMID 9685187.
• Kirchhoff C, Habben I, Ivell R, Krull N (1992). "A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors". Biol. Reprod. 45 (2): 350–7. PMID 1686187.CS1 maint: Multiple names: authors list (link)
• Kirchhoff C, Osterhoff C, Habben I; et al. (1990). "Cloning and analysis of mRNAs expressed specifically in the human epididymis". Int. J. Androl. 13 (2): 155–67. PMID 1693137.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schummer M, Ng WV, Bumgarner RE; et al. (1999). "Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas". Gene. 238 (2): 375–85. PMID 10570965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bingle L, Singleton V, Bingle CD (2002). "The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms". Oncogene. 21 (17): 2768–73. doi:10.1038/sj.onc.1205363. PMID 11965550.CS1 maint: Multiple names: authors list (link)
• Clauss A, Lilja H, Lundwall A (2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein". Biochem. J. 368 (Pt 1): 233–42. doi:10.1042/BJ20020869. PMID 12206714.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hellström I, Raycraft J, Hayden-Ledbetter M; et al. (2003). "The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma". Cancer Res. 63 (13): 3695–700. PMID 12839961.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drapkin R, von Horsten HH, Lin Y; et al. (2005). "Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas". Cancer Res. 65 (6): 2162–9. doi:10.1158/0008-5472.CAN-04-3924. PMID 15781627.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clauss A, Lilja H, Lundwall A (2005). "The evolution of a genetic locus encoding small serine proteinase inhibitors". Biochem. Biophys. Res. Commun. 333 (2): 383–9. doi:10.1016/j.bbrc.2005.05.125. PMID 15950183.CS1 maint: Multiple names: authors list (link)
• Bingle L, Cross SS, High AS; et al. (2006). "WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung". Respir. Res. 7: 61. doi:10.1186/1465-9921-7-61. PMID 16600032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ramachandran P, Boontheung P, Xie Y; et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)