CDH4

Cadherin 4, type 1, R-cadherin (retinal)
Identifiers
Symbols	CDH4 ; CAD4; FLJ22202; FLJ40547; MGC126700; MGC138355; RCAD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48044
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, is a human gene.

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.

Further reading

• Tagliarini F (1977). "[Relations between social defense and criminological trends from the 1930s until today]". Quaderni di criminologia clinica. 18 (3): 289–352. PMID 798233.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. PMID 2059658.CS1 maint: Multiple names: authors list (link)
• Tanihara H, Sano K, Heimark RL; et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. PMID 7982033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.CS1 maint: Multiple names: authors list (link)
• Kools P, Vanhalst K, van Roy F (1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet. Cell Genet. 86 (1): 26–7. PMID 10516427.CS1 maint: Multiple names: authors list (link)
• Shan WS, Tanaka H, Phillips GR; et al. (2000). "Functional cis-heterodimers of N- and R-cadherins". J. Cell Biol. 148 (3): 579–90. PMID 10662782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lecanda F, Cheng SL, Shin CS; et al. (2000). "Differential regulation of cadherins by dexamethasone in human osteoblastic cells". J. Cell. Biochem. 77 (3): 499–506. PMID 10760957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitagawa M, Natori M, Murase S; et al. (2000). "Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function". Biochem. Biophys. Res. Commun. 271 (2): 358–63. doi:10.1006/bbrc.2000.2636. PMID 10799302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Johnson E, Theisen CS, Johnson KR, Wheelock MJ (2004). "R-cadherin influences cell motility via Rho family GTPases". J. Biol. Chem. 279 (30): 31041–9. doi:10.1074/jbc.M400024200. PMID 15143071.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miotto E, Sabbioni S, Veronese A; et al. (2005). "Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer". Cancer Res. 64 (22): 8156–9. doi:10.1158/0008-5472.CAN-04-3000. PMID 15548679.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maeda M, Johnson E, Mandal SH; et al. (2006). "Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn)". Oncogene. 25 (33): 4595–604. doi:10.1038/sj.onc.1209396. PMID 16786001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)