NXT1

NTF2-like export factor 1
File:PBB Protein NXT1 image.jpg PDB rendering based on 1jkg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jkg​, 1jn5​
Identifiers
Symbols	NXT1 ; P15; MTR2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 8301
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NXT1 218708 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

NTF2-like export factor 1, also known as NXT1, is a human gene.

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

Further reading

• Katahira J, Strässer K, Podtelejnikov A; et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–609. doi:10.1093/emboj/18.9.2593. PMID 10228171.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Black BE, Lévesque L, Holaska JM; et al. (2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol. Cell. Biol. 19 (12): 8616–24. PMID 10567585.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ossareh-Nazari B, Maison C, Black BE; et al. (2000). "RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro". Mol. Cell. Biol. 20 (13): 4562–71. PMID 10848583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herold A, Suyama M, Rodrigues JP; et al. (2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Mol. Cell. Biol. 20 (23): 8996–9008. PMID 11073998.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Black BE, Holaska JM, Lévesque L; et al. (2001). "NXT1 is necessary for the terminal step of Crm1-mediated nuclear export". J. Cell Biol. 152 (1): 141–55. PMID 11149927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guzik BW, Levesque L, Prasad S; et al. (2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol. Cell. Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMID 11259602.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jun L, Frints S, Duhamel H; et al. (2002). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Curr. Biol. 11 (18): 1381–91. PMID 11566096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fribourg S, Braun IC, Izaurralde E, Conti E (2001). "Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor". Mol. Cell. 8 (3): 645–56. PMID 11583626.CS1 maint: Multiple names: authors list (link)
• Wiegand HL, Coburn GA, Zeng Y; et al. (2002). "Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes". Mol. Cell. Biol. 22 (1): 245–56. PMID 11739738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katahira J, Straesser K, Saiwaki T; et al. (2002). "Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling". J. Biol. Chem. 277 (11): 9242–6. doi:10.1074/jbc.M110007200. PMID 11756420.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)