CBR1

Carbonyl reductase 1
PDB rendering based on 1wma.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wma​
Identifiers
Symbols	CBR1 ; CBR; hCBR1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37524
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Carbonyl reductase 1, also known as CBR1, is a human gene.

Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.

Further reading

• Wirth H, Wermuth B (1992). "Immunohistochemical localization of carbonyl reductase in human tissues". J. Histochem. Cytochem. 40 (12): 1857–63. PMID 1453004.
• Inazu N, Ruepp B, Wirth H, Wermuth B (1992). "Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis". Biochim. Biophys. Acta. 1116 (1): 50–6. PMID 1540623.CS1 maint: Multiple names: authors list (link)
• Forrest GL, Akman S, Doroshow J; et al. (1991). "Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity". Mol. Pharmacol. 40 (4): 502–7. PMID 1921984.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Forrest GL, Akman S, Krutzik S; et al. (1990). "Induction of a human carbonyl reductase gene located on chromosome 21". Biochim. Biophys. Acta. 1048 (2–3): 149–55. PMID 2182121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wermuth B, Platts KL, Seidel A, Oesch F (1986). "Carbonyl reductase provides the enzymatic basis of quinone detoxication in man". Biochem. Pharmacol. 35 (8): 1277–82. PMID 3083821.CS1 maint: Multiple names: authors list (link)
• Wermuth B, Bohren KM, Heinemann G; et al. (1988). "Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein". J. Biol. Chem. 263 (31): 16185–8. PMID 3141401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bohren KM, von Wartburg JP, Wermuth B (1987). "Kinetics of carbonyl reductase from human brain". Biochem. J. 244 (1): 165–71. PMID 3311025.CS1 maint: Multiple names: authors list (link)
• Wermuth B (1981). "Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase". J. Biol. Chem. 256 (3): 1206–13. PMID 7005231.
• Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis". Eur. J. Biochem. 228 (2): 473–9. PMID 7705364.CS1 maint: Multiple names: authors list (link)
• Krook M, Ghosh D, Strömberg R; et al. (1993). "Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 502–6. PMID 8421682.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemieux N, Malfoy B, Forrest GL (1993). "Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells". Genomics. 15 (1): 169–72. doi:10.1006/geno.1993.1024. PMID 8432528.CS1 maint: Multiple names: authors list (link)
• Watanabe K, Sugawara C, Ono A; et al. (1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tinguely JN, Wermuth B (1999). "Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase". Eur. J. Biochem. 260 (1): 9–14. PMID 10091578.
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finckh C, Atalla A, Nagel G; et al. (2001). "Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung". Chem. Biol. Interact. 130-132 (1–3): 761–73. PMID 11306092.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Balcz B, Kirchner L, Cairns N; et al. (2002). "Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (61): 193–201. PMID 11771743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skálová L, Nobilis M, Szotáková B; et al. (2002). "Carbonyl reduction of the potential cytostatic drugs benfluron and 3,9-dimethoxybenfluron in human in vitro". Biochem. Pharmacol. 64 (2): 297–305. PMID 12123751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheon MS, Shim KS, Kim SH; et al. (2004). "Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV)". Amino Acids. 25 (1): 41–7. doi:10.1007/s00726-003-0009-9. PMID 12836057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)