MAP3K7IP1

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1
File:PBB Protein MAP3K7IP1 image.jpg PDB rendering based on 2j4o.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2j4o​
Identifiers
Symbols	MAP3K7IP1 ; MGC57664; TAB1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4461
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE MAP3K7IP1 203901 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitogen-activated protein kinase kinase kinase 7 interacting protein 1, also known as MAP3K7IP1, is a human gene.

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Shibuya H, Yamaguchi K, Shirakabe K; et al. (1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction". Science. 272 (5265): 1179–82. PMID 8638164.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kurozumi K, Nishita M, Yamaguchi K; et al. (1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells. 3 (4): 257–64. PMID 9663660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaguchi K, Nagai S, Ninomiya-Tsuji J; et al. (1999). "XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway". EMBO J. 18 (1): 179–87. doi:10.1093/emboj/18.1.179. PMID 9878061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ninomiya-Tsuji J, Kishimoto K, Hiyama A; et al. (1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6. doi:10.1038/18465. PMID 10094049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai H, Miyoshi H, Toriumi W, Sugita T (1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation". J. Biol. Chem. 274 (15): 10641–8. PMID 10187861.CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kishimoto K, Matsumoto K, Ninomiya-Tsuji J (2000). "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop". J. Biol. Chem. 275 (10): 7359–64. PMID 10702308.CS1 maint: Multiple names: authors list (link)
• Sakurai H, Miyoshi H, Mizukami J, Sugita T (2000). "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1". FEBS Lett. 474 (2–3): 141–5. PMID 10838074.CS1 maint: Multiple names: authors list (link)
• Ono K, Ohtomo T, Sato S; et al. (2001). "An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK". J. Biol. Chem. 276 (26): 24396–400. doi:10.1074/jbc.M102631200. PMID 11323434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qian Y, Commane M, Ninomiya-Tsuji J; et al. (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B.". J. Biol. Chem. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yanagisawa M, Nakashima K, Takeda K; et al. (2002). "Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7". Genes Cells. 6 (12): 1091–9. PMID 11737269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ge B, Gram H, Di Padova F; et al. (2002). "MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha". Science. 295 (5558): 1291–4. doi:10.1126/science.1067289. PMID 11847341.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai H, Nishi A, Sato N; et al. (2002). "TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways". Biochem. Biophys. Res. Commun. 297 (5): 1277–81. PMID 12372426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ge B, Xiong X, Jing Q; et al. (2003). "TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1". J. Biol. Chem. 278 (4): 2286–93. doi:10.1074/jbc.M210918200. PMID 12429732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishitani T, Kishida S, Hyodo-Miura J; et al. (2003). "The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (1): 131–9. PMID 12482967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzawa M, Takada I, Yanagisawa J; et al. (2003). "Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade". Nat. Cell Biol. 5 (3): 224–30. doi:10.1038/ncb942. PMID 12598905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanno M, Bassi R, Gorog DA; et al. (2003). "Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia". Circ. Res. 93 (3): 254–61. doi:10.1161/01.RES.0000083490.43943.85. PMID 12829618.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Channavajhala PL, Wu L, Cuozzo JW; et al. (2004). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. doi:10.1074/jbc.M306002200. PMID 12975377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMID 14670075.CS1 maint: Multiple names: authors list (link)