CRKL

V-crk sarcoma virus CT10 oncogene homolog (avian)-like
PDB rendering based on 2bzx.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bzx​, 2bzy​, 2dbk​
Identifiers
Symbols	CRKL ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38021
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

V-crk sarcoma virus CT10 oncogene homolog (avian)-like, also known as CRKL, is a human gene.

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.

Further reading

• Feller SM, Posern G, Voss J; et al. (1999). "Physiological signals and oncogenesis mediated through Crk family adapter proteins". J. Cell. Physiol. 177 (4): 535–52. doi:10.1002/(SICI)1097-4652(199812)177:4<535::AID-JCP5>3.0.CO;2-E. PMID 10092207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salgia R, Uemura N, Okuda K; et al. (1996). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". J. Biol. Chem. 270 (49): 29145–50. PMID 7493940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ren R, Ye ZS, Baltimore D (1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes Dev. 8 (7): 783–95. PMID 7926767.CS1 maint: Multiple names: authors list (link)
• Oda T, Heaney C, Hagopian JR; et al. (1994). "Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia". J. Biol. Chem. 269 (37): 22925–8. PMID 8083188.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• ten Hoeve J, Morris C, Heisterkamp N, Groffen J (1993). "Isolation and chromosomal localization of CRKL, a human crk-like gene". Oncogene. 8 (9): 2469–74. PMID 8361759.CS1 maint: Multiple names: authors list (link)
• Smit L, van der Horst G, Borst J (1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". J. Biol. Chem. 271 (15): 8564–9. PMID 8621483.CS1 maint: Multiple names: authors list (link)
• Senechal K, Halpern J, Sawyers CL (1996). "The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene". J. Biol. Chem. 271 (38): 23255–61. PMID 8798523.CS1 maint: Multiple names: authors list (link)
• Salgia R, Pisick E, Sattler M; et al. (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". J. Biol. Chem. 271 (41): 25198–203. PMID 8810278.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ingham RJ, Krebs DL, Barbazuk SM; et al. (1997). "B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins". J. Biol. Chem. 271 (50): 32306–14. PMID 8943292.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heaney C, Kolibaba K, Bhat A; et al. (1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood. 89 (1): 297–306. PMID 8978305.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manié SN, Beck AR, Astier A; et al. (1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". J. Biol. Chem. 272 (7): 4230–6. PMID 9020138.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Jong R, ten Hoeve J, Heisterkamp N, Groffen J (1997). "Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site". Oncogene. 14 (5): 507–13. doi:10.1038/sj.onc.1200885. PMID 9053848.CS1 maint: Multiple names: authors list (link)
• Uemura N, Salgia R, Li JL; et al. (1997). "The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376–85. PMID 9067577.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sattler M, Salgia R, Shrikhande G; et al. (1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". J. Biol. Chem. 272 (15): 10248–53. PMID 9092574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sattler M, Salgia R, Shrikhande G; et al. (1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". J. Biol. Chem. 272 (22): 14320–6. PMID 9162067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Husson H, Mograbi B, Schmid-Antomarchi H; et al. (1997). "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene. 14 (19): 2331–8. doi:10.1038/sj.onc.1201074. PMID 9178909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chin H, Saito T, Arai A; et al. (1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochem. Biophys. Res. Commun. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahmad S, Alsayed YM, Druker BJ, Platanias LC (1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". J. Biol. Chem. 272 (48): 29991–4. PMID 9374471.CS1 maint: Multiple names: authors list (link)
• de Jong R, van Wijk A, Haataja L; et al. (1998). "BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl". J. Biol. Chem. 272 (51): 32649–55. PMID 9405482.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gesbert F, Garbay C, Bertoglio J (1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". J. Biol. Chem. 273 (7): 3986–93. PMID 9461587.CS1 maint: Multiple names: authors list (link)