MMP11

Matrix metallopeptidase 11 (stromelysin 3)
File:PBB Protein MMP11 image.jpg PDB rendering based on 1hv5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hv5​
Identifiers
Symbols	MMP11 ; SL-3; ST3; STMY3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38116
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MMP11 203878 s at tn.png
File:PBB GE MMP11 203876 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Matrix metallopeptidase 11 (stromelysin 3), also known as MMP11, is a human gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Further reading

• Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. PMID 10419448.
• Levy A, Zucman J, Delattre O; et al. (1992). "Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22". Genomics. 13 (3): 881–3. PMID 1639418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Basset P, Bellocq JP, Wolf C; et al. (1991). "A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas". Nature. 348 (6303): 699–704. doi:10.1038/348699a0. PMID 1701851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pei D, Majmudar G, Weiss SJ (1994). "Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3". J. Biol. Chem. 269 (41): 25849–55. PMID 7523394.CS1 maint: Multiple names: authors list (link)
• Anglard P, Melot T, Guérin E; et al. (1995). "Structure and promoter characterization of the human stromelysin-3 gene". J. Biol. Chem. 270 (35): 20337–44. PMID 7657606.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pei D, Weiss SJ (1995). "Furin-dependent intracellular activation of the human stromelysin-3 zymogen". Nature. 375 (6528): 244–7. doi:10.1038/375244a0. PMID 7746327.
• Boulay A, Masson R, Chenard MP; et al. (2001). "High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase". Cancer Res. 61 (5): 2189–93. PMID 11280785.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perret AG, Duthel R, Fotso MJ; et al. (2002). "Stromelysin-3 is expressed by aggressive meningiomas". Cancer. 94 (3): 765–72. PMID 11857311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo D, Mari B, Stoll I, Anglard P (2002). "Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase". J. Biol. Chem. 277 (28): 25527–36. doi:10.1074/jbc.M202494200. PMID 12006591.CS1 maint: Multiple names: authors list (link)
• Nakopoulou L, Panayotopoulou EG, Giannopoulou I; et al. (2003). "Stromelysin-3 protein expression in invasive breast cancer: relation to proliferation, cell survival and patients' outcome". Mod. Pathol. 15 (11): 1154–61. doi:10.1097/01.MP.0000037317.84782.CD. PMID 12429794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wasenius VM, Hemmer S, Kettunen E; et al. (2003). "Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study". Clin. Cancer Res. 9 (1): 68–75. PMID 12538453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fromigué O, Louis K, Wu E; et al. (2003). "Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase". Int. J. Cancer. 106 (3): 355–63. doi:10.1002/ijc.11232. PMID 12845673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skoglund J, Emterling A, Arbman G; et al. (2004). "Clinicopathological significance of stromelysin-3 expression in colorectal cancer". Oncology. 67 (1): 67–72. doi:10.1159/000080288. PMID 15459498.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Louis K, Guérineau N, Fromigué O; et al. (2005). "Tumor cell-mediated induction of the stromal factor stromelysin-3 requires heterotypic cell contact-dependent activation of specific protein kinase C isoforms". J. Biol. Chem. 280 (2): 1272–83. doi:10.1074/jbc.M405482200. PMID 15509588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deng H, Guo RF, Li WM; et al. (2005). "Matrix metalloproteinase 11 depletion inhibits cell proliferation in gastric cancer cells". Biochem. Biophys. Res. Commun. 326 (2): 274–81. doi:10.1016/j.bbrc.2004.11.027. PMID 15582574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arora S, Kaur J, Sharma C; et al. (2005). "Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis". Clin. Cancer Res. 11 (6): 2272–84. doi:10.1158/1078-0432.CCR-04-0572. PMID 15788677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K; et al. (2006). "Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer". BMC Cancer. 5 (1): 68. doi:10.1186/1471-2407-5-68. PMID 15989693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)