MED15

Revision as of 19:17, 4 September 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search


PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
File:PBB Protein PCQAP image.jpg
PDB rendering based on 2gut.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols PCQAP ; TIG1; ARC105; CAG7A; CTG7A; DKFZp686A2214; DKFZp762B1216; FLJ42282; FLJ42935; MED15; TIG-1; TNRC7
External IDs Template:OMIM5 Template:MGI HomoloGene: 32283
RNA expression pattern
File:PBB GE PCQAP 222175 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, also known as PCQAP, is a human gene.[1]

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PCQAP PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein".

Further reading

  • Margolis RL, Abraham MR, Gatchell SB; et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114–22. PMID 9225980.
  • Näär AM, Beaurang PA, Zhou S; et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
  • Abraham S, Solomon WB (2000). "A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues". Gene. 255 (2): 389–400. PMID 11024300.
  • Berti L, Mittler G, Przemeck GK; et al. (2001). "Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit". Genomics. 74 (3): 320–32. doi:10.1006/geno.2001.6566. PMID 11414760.
  • Kato Y, Habas R, Katsuyama Y; et al. (2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling". Nature. 418 (6898): 641–6. doi:10.1038/nature00969. PMID 12167862.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • De Luca A, Conti E, Grifone N; et al. (2003). "Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 116 (1): 32–5. doi:10.1002/ajmg.b.10008. PMID 12497610.
  • Zhang J, Liu L, Pfeifer GP (2004). "Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene". Oncogene. 23 (12): 2241–9. doi:10.1038/sj.onc.1207328. PMID 14691453.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Yang F, DeBeaumont R, Zhou S, Näär AM (2004). "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2339–44. PMID 14983011.
  • Sato S, Tomomori-Sato C, Parmely TJ; et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
  • Sandhu HK, Hollenbeck N, Wassink TH, Philibert RA (2005). "An association study of PCQAP polymorphisms and schizophrenia". Psychiatr. Genet. 14 (3): 169–72. PMID 15318033.
  • Kwong J, Lo KW, Chow LS; et al. (2005). "Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma". Int. J. Cancer. 113 (3): 386–92. doi:10.1002/ijc.20593. PMID 15455391.
  • Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Yang F, Vought BW, Satterlee JS; et al. (2006). "An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis". Nature. 442 (7103): 700–4. doi:10.1038/nature04942. PMID 16799563.
  • Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669.

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=MED15&oldid=718570"