EIF4ENIF1

Eukaryotic translation initiation factor 4E nuclear import factor 1
Identifiers
Symbols	EIF4ENIF1 ; 4E-T; Clast4; FLJ21601; FLJ26551
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10522
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 4E nuclear import factor 1, also known as EIF4ENIF1, is a human gene.

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.

Further reading

• Dostie J, Ferraiuolo M, Pause A; et al. (2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E". EMBO J. 19 (12): 3142–56. doi:10.1093/emboj/19.12.3142. PMID 10856257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warner DR, Roberts EA, Greene RM, Pisano MM (2004). "Identification of novel Smad binding proteins". Biochem. Biophys. Res. Commun. 312 (4): 1185–90. PMID 14651998.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballif BA, Villén J, Beausoleil SA; et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andrei MA, Ingelfinger D, Heintzmann R; et al. (2005). "A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies". RNA. 11 (5): 717–27. doi:10.1261/rna.2340405. PMID 15840819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferraiuolo MA, Basak S, Dostie J; et al. (2005). "A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay". J. Cell Biol. 170 (6): 913–24. doi:10.1083/jcb.200504039. PMID 16157702.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMID 16699599.CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denoeud F, Kapranov P, Ucla C; et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMID 17567994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)