RANGAP1

Ran GTPase activating protein 1
File:PBB Protein RANGAP1 image.jpg PDB rendering based on 1z5s.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1z5s​, 2grn​, 2gro​, 2grp​, 2grq​, 2grr​, 2io2​, 2io3​, 2iy0​
Identifiers
Symbols	RANGAP1 ; Fug1; KIAA1835; MGC20266; SD
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55700
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE RANGAP1 212125 at tn.png
File:PBB GE RANGAP1 212127 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ran GTPase activating protein 1, also known as RANGAP1, is a human gene.

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Further reading

• Becker J, Melchior F, Gerke V; et al. (1995). "RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae". J. Biol. Chem. 270 (20): 11860–5. PMID 7744835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bischoff FR, Krebber H, Kempf T; et al. (1995). "Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1749–53. PMID 7878053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bischoff FR, Klebe C, Kretschmer J; et al. (1994). "RanGAP1 induces GTPase activity of nuclear Ras-related Ran". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2587–91. PMID 8146159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krebber H, Ponstingl H (1997). "Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1". Gene. 180 (1–2): 7–11. PMID 8973340.
• Matunis MJ, Coutavas E, Blobel G (1997). "A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex". J. Cell Biol. 135 (6 Pt 1): 1457–70. PMID 8978815.CS1 maint: Multiple names: authors list (link)
• Mahajan R, Delphin C, Guan T; et al. (1997). "A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2". Cell. 88 (1): 97–107. PMID 9019411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Görlich D, Dabrowski M, Bischoff FR; et al. (1997). "A novel class of RanGTP binding proteins". J. Cell Biol. 138 (1): 65–80. PMID 9214382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheffzek K, Ahmadian MR, Kabsch W; et al. (1998). "The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants". Science. 277 (5324): 333–8. PMID 9219684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahajan R, Gerace L, Melchior F (1998). "Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association". J. Cell Biol. 140 (2): 259–70. PMID 9442102.CS1 maint: Multiple names: authors list (link)
• Kamitani T, Kito K, Nguyen HP; et al. (1998). "Characterization of a second member of the sentrin family of ubiquitin-like proteins". J. Biol. Chem. 273 (18): 11349–53. PMID 9556629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okuma T, Honda R, Ichikawa G; et al. (1999). "In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2". Biochem. Biophys. Res. Commun. 254 (3): 693–8. doi:10.1006/bbrc.1998.9995. PMID 9920803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillig RC, Renault L, Vetter IR; et al. (1999). "The crystal structure of rna1p: a new fold for a GTPase-activating protein". Mol. Cell. 3 (6): 781–91. PMID 10394366.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Nakayama M, Nakajima D; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. PMID 11347906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD (2002). "Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1". Cell. 108 (3): 345–56. PMID 11853669.CS1 maint: Multiple names: authors list (link)
• Joseph J, Tan SH, Karpova TS; et al. (2002). "SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles". J. Cell Biol. 156 (4): 595–602. doi:10.1083/jcb.200110109. PMID 11854305.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang H, Saitoh H, Matunis MJ (2002). "Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex". Mol. Cell. Biol. 22 (18): 6498–508. PMID 12192048.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Macauley MS, Errington WJ, Okon M; et al. (2005). "Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1". J. Biol. Chem. 279 (47): 49131–7. doi:10.1074/jbc.M408705200. PMID 15355965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)