H2AFY

H2A histone family, member Y
PDB rendering based on 1u35.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1u35​, 1yd9​, 1zr3​, 1zr5​, 2f8n​, 2fxk​
Identifiers
Symbols	H2AFY ; H2A.y; H2A/y; H2AF12M; H2AFJ; MACROH2A1.1; mH2A1; macroH2A1.2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3598
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

H2A histone family, member Y, also known as H2AFY, is a human gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. PMID 9566873.CS1 maint: Multiple names: authors list (link)
• Costanzi C, Pehrson JR (1998). "Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals". Nature. 393 (6685): 599–601. doi:10.1038/31275. PMID 9634239.
• Mao M, Fu G, Wu JS; et al. (1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. PMID 9653160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee Y, Hong M, Kim JW; et al. (1998). "Isolation of cDNA clones encoding human histone macroH2A1 subtypes". Biochim. Biophys. Acta. 1399 (1): 73–7. PMID 9714746.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deng L, de la Fuente C, Fu P; et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chadwick BP, Willard HF (2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum. Mol. Genet. 10 (10): 1101–13. PMID 11331621.
• Deng L, Wang D, de la Fuente C; et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chadwick BP, Willard HF (2002). "Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome". J. Cell Biol. 157 (7): 1113–23. doi:10.1083/jcb.200112074. PMID 12082075.
• Takahashi I, Kameoka Y, Hashimoto K (2002). "MacroH2A1.2 binds the nuclear protein Spop". Biochim. Biophys. Acta. 1591 (1–3): 63–8. PMID 12183056.CS1 maint: Multiple names: authors list (link)
• Ganesan S, Silver DP, Greenberg RA; et al. (2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome". Cell. 111 (3): 393–405. PMID 12419249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Angelov D, Molla A, Perche PY; et al. (2003). "The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling". Mol. Cell. 11 (4): 1033–41. PMID 12718888.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Behrends U, Schneider I, Rössler S; et al. (2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMID 14657027.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P; et al. (2004). "Respiratory complex III is required to maintain complex I in mammalian mitochondria". Mol. Cell. 13 (6): 805–15. PMID 15053874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang R, Poustovoitov MV, Ye X; et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Dev. Cell. 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hernández-Muñoz I, Lund AH, van der Stoop P; et al. (2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7635–40. doi:10.1073/pnas.0408918102. PMID 15897469.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)