FER (gene)

Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)
Identifiers
Symbols	FER ; TYK3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74300
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94), also known as FER, is a human gene.

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.

Further reading

• Greer P (2002). "Closing in on the biological functions of Fps/Fes and Fer". Nat. Rev. Mol. Cell Biol. 3 (4): 278–89. doi:10.1038/nrm783. PMID 11994747.
• Nishisho I, Nakamura Y, Miyoshi Y; et al. (1991). "Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients". Science. 253 (5020): 665–9. PMID 1651563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warrington JA, Hall LV, Hinton LM; et al. (1992). "Radiation hybrid map of 13 loci on the long arm of chromosome 5". Genomics. 11 (3): 701–8. PMID 1663488.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hao QL, Ferris DK, White G; et al. (1991). "Nuclear and cytoplasmic location of the FER tyrosine kinase". Mol. Cell. Biol. 11 (2): 1180–3. PMID 1990274.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krolewski JJ, Lee R, Eddy R; et al. (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–82. PMID 2156206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morris C, Heisterkamp N, Hao QL; et al. (1990). "The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q)". Cytogenet. Cell Genet. 53 (4): 196–200. PMID 2209086.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pawson T, Letwin K, Lee T; et al. (1990). "The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family". Mol. Cell. Biol. 9 (12): 5722–5. PMID 2685575.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hao QL, Heisterkamp N, Groffen J (1989). "Isolation and sequence analysis of a novel human tyrosine kinase gene". Mol. Cell. Biol. 9 (4): 1587–93. PMID 2725517.CS1 maint: Multiple names: authors list (link)
• Brunati AM, Pinna LA (1988). "Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen". Eur. J. Biochem. 172 (2): 451–7. PMID 3350007.
• Meggio F, Brunati AM, Pinna LA (1987). "Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase". FEBS Lett. 215 (2): 241–6. PMID 3472906.CS1 maint: Multiple names: authors list (link)
• Kim L, Wong TW (1995). "The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors". Mol. Cell. Biol. 15 (8): 4553–61. PMID 7623846.
• Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.CS1 maint: Multiple names: authors list (link)
• Kim L, Wong TW (1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER". J. Biol. Chem. 273 (36): 23542–8. PMID 9722593.
• Rosato R, Veltmaat JM, Groffen J, Heisterkamp N (1998). "Involvement of the tyrosine kinase fer in cell adhesion". Mol. Cell. Biol. 18 (10): 5762–70. PMID 9742093.CS1 maint: Multiple names: authors list (link)
• Schwartz Y, Ben-Dor I, Navon A; et al. (1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. PMID 9742951.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang C, Liu J, Haudenschild CC, Zhan X (1998). "The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells". J. Biol. Chem. 273 (40): 25770–6. PMID 9748248.CS1 maint: Multiple names: authors list (link)
• Corti C, Leclerc L'Hostis E, Quadroni M; et al. (1999). "Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins". Eur. J. Biochem. 262 (3): 790–802. PMID 10411641.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Priel-Halachmi S, Ben-Dor I, Shpungin S; et al. (2000). "FER kinase activation of Stat3 is determined by the N-terminal sequence". J. Biol. Chem. 275 (37): 28902–10. doi:10.1074/jbc.M003402200. PMID 10878010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kapus A, Di Ciano C, Sun J; et al. (2000). "Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases". J. Biol. Chem. 275 (41): 32289–98. doi:10.1074/jbc.M003172200. PMID 10921917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orlovsky K, Ben-Dor I, Priel-Halachmi S; et al. (2000). "N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo". Biochemistry. 39 (36): 11084–91. PMID 10998246.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)