HSPA9

Heat shock 70kDa protein 9 (mortalin)
Identifiers
Symbols	HSPA9 ; CSA; GRP75; HSPA9B; MGC4500; MOT; MOT2; MTHSP75; PBP74; mot-2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 39452
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Heat shock 70kDa protein 9 (mortalin), also known as HSPA9, is a human gene.

The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein plays a role in the control of cell proliferation. It may also act as a chaperone.

Further reading

• Kaul SC, Taira K, Pereira-Smith OM, Wadhwa R (2003). "Mortalin: present and prospective". Exp. Gerontol. 37 (10–11): 1157–64. PMID 12470827.CS1 maint: Multiple names: authors list (link)
• Yaguchi T, Aida S, Kaul SC, Wadhwa R (2007). "Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions". Ann. N. Y. Acad. Sci. 1100: 306–11. doi:10.1196/annals.1395.032. PMID 17460192.CS1 maint: Multiple names: authors list (link)
• Hochstrasser DF, Frutiger S, Paquet N; et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. PMID 1286669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Domanico SZ, DeNagel DC, Dahlseid JN; et al. (1993). "Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family". Mol. Cell. Biol. 13 (6): 3598–610. PMID 7684501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaul SC, Wadhwa R, Matsuda Y; et al. (1995). "Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins". FEBS Lett. 361 (2–3): 269–72. PMID 7698336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhattacharyya T, Karnezis AN, Murphy SP; et al. (1995). "Cloning and subcellular localization of human mitochondrial hsp70". J. Biol. Chem. 270 (4): 1705–10. PMID 7829505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furlini G, Vignoli M, Re MC; et al. (1994). "Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein". J. Gen. Virol. 75 ( Pt 1): 193–9. PMID 7906708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matoba R, Okubo K, Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. PMID 8076819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Hughes GJ, Frutiger S, Paquet N; et al. (1994). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. PMID 8313870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ji H, Reid GE, Moritz RL; et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins". Electrophoresis. 18 (3–4): 605–13. doi:10.1002/elps.1150180344. PMID 9150948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mizukoshi E, Suzuki M, Loupatov A; et al. (1999). "Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin". Biochem. J. 343 Pt 2: 461–6. PMID 10510314.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Keeffe B, Fong Y, Chen D; et al. (2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription". J. Biol. Chem. 275 (1): 279–87. PMID 10617616.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaula SC, Reddelb RR, Sugiharac T; et al. (2000). "Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2". FEBS Lett. 474 (2–3): 159–64. PMID 10838077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Agostini I, Popov S, Li J; et al. (2000). "Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex". Exp. Cell Res. 259 (2): 398–403. doi:10.1006/excr.2000.4992. PMID 10964507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie H, Hu Z, Chyna B; et al. (2001). "Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31". Leukemia. 14 (12): 2128–34. PMID 11187902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carette J, Lehnert S, Chow TY (2002). "Implication of PBP74/mortalin/GRP75 in the radio-adaptive response". Int. J. Radiat. Biol. 78 (3): 183–90. doi:10.1080/09553000110097208. PMID 11869473.CS1 maint: Multiple names: authors list (link)
• Wadhwa R, Yaguchi T, Hasan MK; et al. (2002). "Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein". Exp. Cell Res. 274 (2): 246–53. doi:10.1006/excr.2002.5468. PMID 11900485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)