GFRA3

GDNF family receptor alpha 3
PDB rendering based on 2gh0.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2gh0​
Identifiers
Symbols	GFRA3 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1146
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GDNF family receptor alpha 3, also known as GFRA3, is a human gene.

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.

Further reading

• Wang X, Baloh RH, Milbrandt J, Garcia KC (2006). "Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083–92. doi:10.1016/j.str.2006.05.010. PMID 16765900.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gimm O, Dziema H, Brown J; et al. (2001). "Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma". Oncogene. 20 (17): 2161–70. doi:10.1038/sj.onc.1204289. PMID 11360200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Onochie CI, Korngut LM, Vanhorne JB; et al. (2000). "Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease". J. Med. Genet. 37 (9): 674–9. PMID 10978357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baloh RH, Tansey MG, Lampe PA; et al. (1999). "Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex". Neuron. 21 (6): 1291–302. PMID 9883723.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baloh RH, Gorodinsky A, Golden JP; et al. (1998). "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5801–6. PMID 9576965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masure S, Cik M, Pangalos MN; et al. (1998). "Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". Eur. J. Biochem. 251 (3): 622–30. PMID 9490034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jing S, Yu Y, Fang M; et al. (1998). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". J. Biol. Chem. 272 (52): 33111–7. PMID 9407096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)