NNT (gene)

Nicotinamide nucleotide transhydrogenase
File:PBB Protein NNT image.jpg PDB rendering based on 1d4o.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1d4o​, 1djl​, 1pt9​, 1u31​
Identifiers
Symbols	NNT ; MGC126502; MGC126503
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7445
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nicotinamide nucleotide transhydrogenase, also known as NNT, is a human gene.

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.

Further reading

• Jackson JB (2003). "Proton translocation by transhydrogenase". FEBS Lett. 545 (1): 18–24. PMID 12788487.
• Arkblad EL, Betsholtz C, Rydström J (1996). "The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse". Biochim. Biophys. Acta. 1273 (3): 203–5. PMID 8616157.CS1 maint: Multiple names: authors list (link)
• Forsmark-Andrée P, Persson B, Radi R; et al. (1997). "Oxidative modification of nicotinamide nucleotide transhydrogenase in submitochondrial particles: effect of endogenous ubiquinol". Arch. Biochem. Biophys. 336 (1): 113–20. doi:10.1006/abbi.1996.0538. PMID 8951041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arkblad EL, Helou K, Levan G, Rydström J (1997). "Mapping of the rat and mouse nicotinamide nucleotide transhydrogenase gene". Mamm. Genome. 8 (9): 703. PMID 9271681.CS1 maint: Multiple names: authors list (link)
• Zieger B, Ware J (1998). "Cloning and deduced amino acid sequence of human nicotinamide nucleotide transhydrogenase". DNA Seq. 7 (6): 369–73. PMID 9524818.
• White SA, Peake SJ, McSweeney S; et al. (2000). "The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria". Structure. 8 (1): 1–12. PMID 10673423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peake SJ, Jackson JB, White SA (2000). "The NADP(H)-binding component (dIII) of human heart transhydrogenase: crystallization and preliminary crystallographic analysis". Acta Crystallogr. D Biol. Crystallogr. 56 (Pt 4): 489–91. PMID 10739929.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Venter JC, Adams MD, Myers EW; et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arkblad EL, Egorov M, Shakhparonov M; et al. (2003). "Expression of proton-pumping nicotinamide nucleotide transhydrogenase in mouse, human brain and C elegans". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 133 (1): 13–21. PMID 12223207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taylor SW, Fahy E, Zhang B; et al. (2003). "Characterization of the human heart mitochondrial proteome". Nat. Biotechnol. 21 (3): 281–6. doi:10.1038/nbt793. PMID 12592411.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)