PDLIM7

PDZ and LIM domain 7 (enigma)
Identifiers
Symbols	PDLIM7 ;
External IDs	Template:OMIM5 HomoloGene: 3980
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE PDLIM7 203370 s at tn.png
File:PBB GE PDLIM7 203369 x at tn.png
File:PBB GE PDLIM7 214266 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

PDZ and LIM domain 7 (enigma), also known as PDLIM7, is a human gene.

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.

Further reading

• Bach I (2000). "The LIM domain: regulation by association". Mech. Dev. 91 (1–2): 5–17. PMID 10704826.
• Wu RY, Gill GN (1994). "LIM domain recognition of a tyrosine-containing tight turn". J. Biol. Chem. 269 (40): 25085–90. PMID 7929196.
• Kuroda S, Tokunaga C, Kiyohara Y; et al. (1997). "Protein-protein interaction of zinc finger LIM domains with protein kinase C.". J. Biol. Chem. 271 (49): 31029–32. PMID 8940095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Durick K, Gill GN, Taylor SS (1998). "Shc and Enigma are both required for mitogenic signaling by Ret/ptc2". Mol. Cell. Biol. 18 (4): 2298–308. PMID 9528800.CS1 maint: Multiple names: authors list (link)
• Guy PM, Kenny DA, Gill GN (1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Mol. Biol. Cell. 10 (6): 1973–84. PMID 10359609.CS1 maint: Multiple names: authors list (link)
• Liu Y, Hair GA, Boden SD; et al. (2002). "Overexpressed LIM mineralization proteins do not require LIM domains to induce bone". J. Bone Miner. Res. 17 (3): 406–14. PMID 11874232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borrello MG, Mercalli E, Perego C; et al. (2002). "Differential interaction of Enigma protein with the two RET isoforms". Biochem. Biophys. Res. Commun. 296 (3): 515–22. PMID 12176011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sangadala S, Boden SD, Viggeswarapu M; et al. (2006). "LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads". J. Biol. Chem. 281 (25): 17212–9. doi:10.1074/jbc.M511013200. PMID 16611643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrès R, Grémeaux T, Gual P; et al. (2007). "Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation". Mol. Endocrinol. 20 (11): 2864–75. doi:10.1210/me.2005-0455. PMID 16803868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang DW, Li LW, Hu YY (2007). "A novel TAT fusion protein with osteoinductive activity". Med. Hypotheses. 68 (5): 1009–11. doi:10.1016/j.mehy.2006.09.057. PMID 17126496.CS1 maint: Multiple names: authors list (link)