IER3
| Immediate early response 3 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | IER3 ; PRG1; DIF-2; DIF2; GLY96; IEX-1; IEX-1L; IEX1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2894 | ||||||||||
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| RNA expression pattern | |||||||||||
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| File:PBB GE IER3 208748 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Immediate early response 3, also known as IER3, is a human gene.
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.[1]
References
Further reading
- Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis". Apoptosis. 8 (1): 11–8. PMID 12510147.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Kondratyev AD, Chung KN, Jung MO (1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392.
- Schäfer H, Trauzold A, Siegel EG; et al. (1996). "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line". Cancer Res. 56 (11): 2641–8. PMID 8653710.
- Pietzsch A, Büchler C, Aslanidis C, Schmitz G (1997). "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine". Biochem. Biophys. Res. Commun. 235 (1): 4–9. doi:10.1006/bbrc.1997.6715. PMID 9196025.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Pietzsch A, Büchler C, Schmitz G (1998). "Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene". Biochem. Biophys. Res. Commun. 245 (3): 651–7. doi:10.1006/bbrc.1998.8500. PMID 9588170.
- Wu MX, Ao Z, Prasad KV; et al. (1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. PMID 9703517.
- Schäfer H, Diebel J, Arlt A; et al. (1998). "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB". FEBS Lett. 436 (2): 139–43. PMID 9781666.
- Kobayashi T, Pittelkow MR, Warner GM; et al. (1998). "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3". Biochem. Biophys. Res. Commun. 251 (3): 868–73. doi:10.1006/bbrc.1998.9556. PMID 9791001.
- Kumar R, Kobayashi T, Warner GM; et al. (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes". Biochem. Biophys. Res. Commun. 253 (2): 336–41. doi:10.1006/bbrc.1998.9692. PMID 9878538.
- Schäfer H, Arlt A, Trauzold A; et al. (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo". Biochem. Biophys. Res. Commun. 262 (1): 139–45. doi:10.1006/bbrc.1999.1131. PMID 10448082.
- Feldmann KA, Pittelkow MR, Roche PC; et al. (2001). "Expression of an immediate early gene, IEX-1, in human tissues". Histochem. Cell Biol. 115 (6): 489–97. PMID 11455449.
- Zhang Y, Schlossman SF, Edwards RA; et al. (2002). "Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 878–83. doi:10.1073/pnas.022326699. PMID 11782530.
- Im HJ, Pittelkow MR, Kumar R (2002). "Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1". J. Biol. Chem. 277 (17): 14612–21. doi:10.1074/jbc.M109414200. PMID 11844788.
- Ohki R, Yamamoto K, Mano H; et al. (2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays". J. Hypertens. 20 (4): 685–91. PMID 11910304.
- Im HJ, Craig TA, Pittelkow MR, Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression". Oncogene. 21 (23): 3706–14. doi:10.1038/sj.onc.1205450. PMID 12032839.
- Garcia J, Ye Y, Arranz V; et al. (2002). "IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation". EMBO J. 21 (19): 5151–63. PMID 12356731.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
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