CLIC1

Chloride intracellular channel 1
PDB rendering based on 1k0m.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1k0m​, 1k0n​, 1k0o​, 1rk4​
Identifiers
Symbols	CLIC1 ; G6; NCC27
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20343
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chloride intracellular channel 1, also known as CLIC1, is a human gene.

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.

Further reading

• Okubo K, Hori N, Matoba R; et al. (1994). "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression". Nat. Genet. 2 (3): 173–9. doi:10.1038/ng1192-173. PMID 1345164.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frigerio JM, Berthézène P, Garrido P; et al. (1995). "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing". Hum. Mol. Genet. 4 (1): 37–43. PMID 7711732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liew CC, Hwang DM, Fung YW; et al. (1994). "A catalogue of genes in the cardiovascular system as identified by expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10645–9. PMID 7938007.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Valenzuela SM, Martin DK, Por SB; et al. (1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei". J. Biol. Chem. 272 (19): 12575–82. PMID 9139710.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heiss NS, Poustka A (1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28". Genomics. 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID 9339381.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tulk BM, Edwards JC (1998). "NCC27, a homolog of intracellular Cl- channel p64, is expressed in brush border of renal proximal tubule". Am. J. Physiol. 274 (6 Pt 2): F1140–9. PMID 9841507.
• Chuang JZ, Milner TA, Zhu M, Sung CH (1999). "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons". J. Neurosci. 19 (8): 2919–28. PMID 10191309.CS1 maint: Multiple names: authors list (link)
• Ribas G, Neville M, Wixon JL; et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". J. Immunol. 163 (1): 278–87. PMID 10384126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berryman M, Bretscher A (2000). "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli". Mol. Biol. Cell. 11 (5): 1509–21. PMID 10793131.
• Tonini R, Ferroni A, Valenzuela SM; et al. (2000). "Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells". FASEB J. 14 (9): 1171–8. PMID 10834939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valenzuela SM, Mazzanti M, Tonini R; et al. (2001). "The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle". J. Physiol. (Lond.). 529 Pt 3: 541–52. PMID 11195932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harrop SJ, DeMaere MZ, Fairlie WD; et al. (2002). "Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution". J. Biol. Chem. 276 (48): 44993–5000. doi:10.1074/jbc.M107804200. PMID 11551966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warton K, Tonini R, Fairlie WD; et al. (2002). "Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1". J. Biol. Chem. 277 (29): 26003–11. doi:10.1074/jbc.M203666200. PMID 11978800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shanks RA, Larocca MC, Berryman M; et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins". FEBS Lett. 540 (1–3): 77–80. PMID 12681486.CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Littler DR, Harrop SJ, Fairlie WD; et al. (2004). "The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition". J. Biol. Chem. 279 (10): 9298–305. doi:10.1074/jbc.M308444200. PMID 14613939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)