BRD2

Bromodomain containing 2
PDB rendering based on 1x0j.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x0j​, 2g4a​
Identifiers
Symbols	BRD2 ; D6S113E; DKFZp686N0336; FLJ31942; FSRG1; KIAA9001; NAT; RING3; RNF3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74540
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Bromodomain containing 2, also known as BRD2, is a human gene.

This gene encodes a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.

Further reading

• Haynes SR, Dollard C, Winston F; et al. (1992). "The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins". Nucleic Acids Res. 20 (10): 2603. PMID 1350857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beck S, Hanson I, Kelly A; et al. (1992). "A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC". DNA Seq. 2 (4): 203–10. PMID 1352711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okamoto N, Ando A, Kawai J; et al. (1992). "Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region". Hum. Immunol. 32 (3): 221–8. PMID 1663500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denis GV, Green MR (1996). "A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator". Genes Dev. 10 (3): 261–71. PMID 8595877.
• Thorpe KL, Abdulla S, Kaufman J; et al. (1996). "Phylogeny and structure of the RING3 gene". Immunogenetics. 44 (5): 391–6. PMID 8781126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thorpe KL, Gorman P, Thomas C; et al. (1997). "Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene". Gene. 200 (1–2): 177–83. PMID 9373153.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniguchi Y, Matsuzaka Y, Fujimoto H; et al. (1998). "Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells". Genomics. 51 (1): 114–23. doi:10.1006/geno.1998.5262. PMID 9693039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo N, Faller DV, Denis GV (2000). "Activation-induced nuclear translocation of RING3". J. Cell. Sci. 113 ( Pt 17): 3085–91. PMID 10934046.CS1 maint: Multiple names: authors list (link)
• Denis GV, Vaziri C, Guo N, Faller DV (2001). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. PMID 10965846.CS1 maint: Multiple names: authors list (link)
• BelAiba RS, Baril P, Chebloune Y; et al. (2001). "Identification and cloning of an 85-kDa protein homologous to RING3 that is upregulated in proliferating endothelial cells". Eur. J. Biochem. 268 (16): 4398–407. PMID 11502199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Crowley TE, Kaine EM, Yoshida M; et al. (2003). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. PMID 12145330.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou M, Peng C, Nie XM; et al. (2003). "[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]". Ai Zheng. 22 (2): 123–7. PMID 12600283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pal DK, Evgrafov OV, Tabares P; et al. (2003). "BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy". Am. J. Hum. Genet. 73 (2): 261–70. PMID 12830434.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanno T, Kanno Y, Siegel RM; et al. (2004). "Selective recognition of acetylated histones by bromodomain proteins visualized in living cells". Mol. Cell. 13 (1): 33–43. PMID 14731392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benevolenskaya EV, Murray HL, Branton P; et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)