HIST1H2BK

Histone cluster 1, H2bk
File:PBB Protein HIST1H2BK image.jpg PDB rendering based on 1aoi.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1aoi​, 1eqz​, 1f66​, 1hio​, 1hq3​, 1kx3​, 1kx4​, 1kx5​, 1m18​, 1m19​, 1m1a​, 1p34​, 1p3a​, 1p3b​, 1p3f​, 1p3g​, 1p3i​, 1p3k​, 1p3l​, 1p3m​, 1p3o​, 1p3p​, 1s32​, 1tzy​, 1u35​, 1zbb​, 1zla​, 2aro​, 2cv5​, 2f8n​, 2fj7​, 2hio​, 2nzd​
Identifiers
Symbols	HIST1H2BK ; H2B/S; H2BFAiii; H2BFT; MGC131989
External IDs	HomoloGene: 89090
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE HIST1H2BK 208579 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Histone cluster 1, H2bk, also known as HIST1H2BK, is a human gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.

Further reading

• Dobner T, Wolf I, Mai B, Lipp M (1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq. 1 (6): 409–13. PMID 1768865.CS1 maint: Multiple names: authors list (link)
• Frohm M, Gunne H, Bergman AC; et al. (1996). "Biochemical and antibacterial analysis of human wound and blister fluid". Eur. J. Biochem. 237 (1): 86–92. PMID 8620898.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. PMID 9566873.CS1 maint: Multiple names: authors list (link)
• Lorain S, Quivy JP, Monier-Gavelle F; et al. (1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol. Cell. Biol. 18 (9): 5546–56. PMID 9710638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Albig W, Trappe R, Kardalinou E; et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. PMID 10064132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome. 10 (7): 768–70. PMID 10384058.
• Deng L, de la Fuente C, Fu P; et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deng L, Wang D, de la Fuente C; et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim HS, Cho JH, Park HW; et al. (2002). "Endotoxin-neutralizing antimicrobial proteins of the human placenta". J. Immunol. 168 (5): 2356–64. PMID 11859126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marzluff WF, Gongidi P, Woods KR; et al. (2003). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. PMID 12408966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheung WL, Ajiro K, Samejima K; et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase". Cell. 113 (4): 507–17. PMID 12757711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tollin M, Bergman P, Svenberg T; et al. (2004). "Antimicrobial peptides in the first line defence of human colon mucosa". Peptides. 24 (4): 523–30. PMID 12860195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMID 14657027.CS1 maint: Multiple names: authors list (link)
• Howell SJ, Wilk D, Yadav SP, Bevins CL (2004). "Antimicrobial polypeptides of the human colonic epithelium". Peptides. 24 (11): 1763–70. doi:10.1016/j.peptides.2003.07.028. PMID 15019208.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsunaka Y, Kajimura N, Tate S, Morikawa K (2005). "Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle". Nucleic Acids Res. 33 (10): 3424–34. doi:10.1093/nar/gki663. PMID 15951514.CS1 maint: Multiple names: authors list (link)
• Golebiowski F, Kasprzak KS (2007). "Inhibition of core histones acetylation by carcinogenic nickel(II)". Mol. Cell. Biochem. 279 (1–2): 133–9. doi:10.1007/s11010-005-8285-1. PMID 16283522.