HSPA1L

Heat shock 70kDa protein 1-like
File:PBB Protein HSPA1L image.jpg PDB rendering based on 1hjo.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hjo​, 1s3x​, 1xqs​
Identifiers
Symbols	HSPA1L ; HSP70-HOM; hum70t
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74557
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Heat shock 70kDa protein 1-like, also known as HSPA1L, is a human gene.

This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.

Further reading

• Ishihara M, Ohno S (1997). "Genetic influences on sarcoidosis". Eye (London, England). 11 ( Pt 2): 155–61. PMID 9349405.
• Milner CM, Campbell RD (1992). "Polymorphic analysis of the three MHC-linked HSP70 genes". Immunogenetics. 36 (6): 357–62. PMID 1356099.
• Milner CM, Campbell RD (1990). "Structure and expression of the three MHC-linked HSP70 genes". Immunogenetics. 32 (4): 242–51. PMID 1700760.
• Sargent CA, Dunham I, Trowsdale J, Campbell RD (1989). "Human major histocompatibility complex contains genes for the major heat shock protein HSP70". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1968–72. PMID 2538825.CS1 maint: Multiple names: authors list (link)
• Goate AM, Cooper DN, Hall C; et al. (1987). "Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis". Hum. Genet. 75 (2): 123–8. PMID 2880793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harrison GS, Drabkin HA, Kao FT; et al. (1987). "Chromosomal location of human genes encoding major heat-shock protein HSP70". Somat. Cell Mol. Genet. 13 (2): 119–30. PMID 3470951.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Voellmy R, Ahmed A, Schiller P; et al. (1985). "Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment". Proc. Natl. Acad. Sci. U.S.A. 82 (15): 4949–53. PMID 3927293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito Y, Ando A, Ando H; et al. (1998). "Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man". J. Biochem. 124 (2): 347–53. PMID 9685725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Fourie AM, Peterson PA, Yang Y (2002). "Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2". Cell Stress Chaperones. 6 (3): 282–95. PMID 11599570.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schröder O, Schulte KM, Ostermann P; et al. (2003). "Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury". Crit. Care Med. 31 (1): 73–9. doi:10.1097/01.CCM.0000037972.16578.2B. PMID 12544996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xie T, Rowen L, Aguado B; et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)