SIM1

Single-minded homolog 1 (Drosophila)
Identifiers
Symbols	SIM1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3715
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SIM1 206876 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Single-minded homolog 1 (Drosophila), also known as SIM1, is a human gene.

SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome.

Further reading

• Fan CM, Kuwana E, Bulfone A; et al. (1996). "Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome". Mol. Cell. Neurosci. 7 (1): 1–16. doi:10.1006/mcne.1996.0001. PMID 8812055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O (1997). "Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein". J. Biol. Chem. 272 (7): 4451–7. PMID 9020169.CS1 maint: Multiple names: authors list (link)
• Chrast R, Scott HS, Chen H; et al. (1997). "Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region". Genome Res. 7 (6): 615–24. PMID 9199934.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holder JL, Butte NF, Zinn AR (2000). "Profound obesity associated with a balanced translocation that disrupts the SIM1 gene". Hum. Mol. Genet. 9 (1): 101–8. PMID 10587584.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Michaud JL, Boucher F, Melnyk A; et al. (2001). "Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus". Hum. Mol. Genet. 10 (14): 1465–73. PMID 11448938.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Woods SL, Whitelaw ML (2002). "Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". J. Biol. Chem. 277 (12): 10236–43. doi:10.1074/jbc.M110752200. PMID 11782478.
• Faivre L, Cormier-Daire V, Lapierre JM; et al. (2002). "Deletion of the SIM1 gene (6q16.2) in a patient with a Prader-Willi-like phenotype". J. Med. Genet. 39 (8): 594–6. PMID 12161602.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamaki A, Kudoh J, Shimizu N, Shimizu Y (2004). "A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2". Biochem. Biophys. Res. Commun. 313 (3): 482–8. PMID 14697214.CS1 maint: Multiple names: authors list (link)
• Meyre D, Lecoeur C, Delplanque J; et al. (2004). "A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2". Diabetes. 53 (3): 803–11. PMID 14988267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kublaoui BM, Holder JL, Tolson KP; et al. (2006). "SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake". Endocrinology. 147 (10): 4542–9. doi:10.1210/en.2006-0453. PMID 16709610.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)