VNN2

Vanin 2
Identifiers
Symbols	VNN2 ; FOAP-4; GPI-80
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48295
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VNN2 205922 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Vanin 2, also known as VNN2, is a human gene.

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Two transcript variants encoding different isoforms have been described for this gene.

Further reading

• Galland F, Malergue F, Bazin H; et al. (1998). "Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6". Genomics. 53 (2): 203–13. doi:10.1006/geno.1998.5481. PMID 9790769.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki K, Watanabe T, Sakurai S; et al. (1999). "A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration". J. Immunol. 162 (7): 4277–84. PMID 10201959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dahlgren C, Karlsson A, Sendo F (2001). "Neutrophil secretory vesicles are the intracellular reservoir for GPI-80, a protein with adhesion-regulating potential". J. Leukoc. Biol. 69 (1): 57–62. PMID 11200068.CS1 maint: Multiple names: authors list (link)
• Martin F, Malergue F, Pitari G; et al. (2001). "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes". Immunogenetics. 53 (4): 296–306. PMID 11491533.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Watanabe T, Sendo F (2002). "Physical association of beta 2 integrin with GPI-80, a novel glycosylphosphatidylinositol-anchored protein with potential for regulating adhesion and migration". Biochem. Biophys. Res. Commun. 294 (3): 692–4. doi:10.1016/S0006-291X(02)00538-7. PMID 12056825.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeda Y, Fu J, Suzuki K; et al. (2003). "Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells". Exp. Cell Res. 286 (2): 199–208. PMID 12749849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sendo D, Takeda Y, Ishikawa H; et al. (2004). "Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes". Immunobiology. 207 (3): 217–21. PMID 12777063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasaki H, Ide N, Sendo F; et al. (2004). "Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage". Cancer Sci. 94 (9): 809–13. PMID 12967480.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshitake H, Takeda Y, Nitto T; et al. (2004). "GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration". Immunobiology. 208 (4): 391–9. PMID 14748512.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu T, Qian WJ, Gritsenko MA; et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nitto T, Takeda Y, Yoshitake H; et al. (2007). "Structural divergence of GPI-80 in activated human neutrophils". Biochem. Biophys. Res. Commun. 359 (2): 227–33. doi:10.1016/j.bbrc.2007.05.087. PMID 17543284.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)