MAP7

Microtubule-associated protein 7
Identifiers
Symbols	MAP7 ; E-MAP-115; EMAP115
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20851
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP7 202889 x at tn.png
File:PBB GE MAP7 215471 s at tn.png
File:PBB GE MAP7 202890 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Microtubule-associated protein 7, also known as MAP7, is a human gene.

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis.

Further reading

• Masson D, Kreis TE (1996). "Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation". J. Cell Biol. 131 (4): 1015–24. PMID 7490279.
• Masson D, Kreis TE (1993). "Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells". J. Cell Biol. 123 (2): 357–71. PMID 8408219.
• Fabre-Jonca N, Viard I, French LE, Masson D (1999). "Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts". J. Invest. Dermatol. 112 (2): 216–25. doi:10.1046/j.1523-1747.1999.00500.x. PMID 9989799.CS1 maint: Multiple names: authors list (link)
• Bulinski JC, Odde DJ, Howell BJ; et al. (2002). "Rapid dynamics of the microtubule binding of ensconsin in vivo". J. Cell. Sci. 114 (Pt 21): 3885–97. PMID 11719555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Penttilä TL, Parvinen M, Paranko J (2004). "Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette". Int. J. Androl. 26 (3): 166–74. PMID 12755995.CS1 maint: Multiple names: authors list (link)
• Vanier MT, Deck P, Stutzmann J; et al. (2004). "Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells". Cell Motil. Cytoskeleton. 55 (4): 221–31. doi:10.1002/cm.10124. PMID 12845596.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki M, Hirao A, Mizuno A (2004). "Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)". J. Biol. Chem. 278 (51): 51448–53. doi:10.1074/jbc.M308212200. PMID 14517216.CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sood R, Bader PI, Speer MC; et al. (2004). "Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis". Cytogenet. Genome Res. 106 (1): 61–7. doi:10.1159/000078563. PMID 15218243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)