SRPK1

SFRS protein kinase 1
File:PBB Protein SRPK1 image.jpg PDB rendering based on 1wak.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1wak​, 1wbp​
Identifiers
Symbols	SRPK1 ; SFRSK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74461
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SRPK1 202199 s at tn.png
File:PBB GE SRPK1 202200 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

SFRS protein kinase 1, also known as SRPK1, is a human gene.

This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.

Further reading

• Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.CS1 maint: Multiple names: authors list (link)
• Colwill K, Feng LL, Yeakley JM; et al. (1996). "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. Chem. 271 (40): 24569–75. PMID 8798720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang HY, Lin W, Dyck JA; et al. (1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. PMID 9472028.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papoutsopoulou S, Nikolakaki E, Giannakouros T (1999). "SRPK1 and LBR protein kinases show identical substrate specificities". Biochem. Biophys. Res. Commun. 255 (3): 602–7. doi:10.1006/bbrc.1999.0249. PMID 10049757.CS1 maint: Multiple names: authors list (link)
• Koizumi J, Okamoto Y, Onogi H; et al. (1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. PMID 10196197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang HY, Arden KC, Bermingham JR; et al. (1999). "Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes". Genomics. 57 (2): 310–5. doi:10.1006/geno.1999.5770. PMID 10198174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paillard F (1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia". Hum. Gene Ther. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
• Papoutsopoulou S, Nikolakaki E, Chalepakis G; et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. PMID 10390541.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nikolakaki E, Kohen R, Hartmann AM; et al. (2001). "Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B". J. Biol. Chem. 276 (43): 40175–82. doi:10.1074/jbc.M104755200. PMID 11509566.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daub H, Blencke S, Habenberger P; et al. (2002). "Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein". J. Virol. 76 (16): 8124–37. PMID 12134018.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamachi M, Le TM, Kim SJ; et al. (2003). "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". J. Exp. Med. 196 (9): 1213–25. PMID 12417631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mylonis I, Giannakouros T (2003). "Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1". Biochem. Biophys. Res. Commun. 301 (3): 650–6. PMID 12565829.
• Aubol BE, Chakrabarti S, Ngo J; et al. (2004). "Processive phosphorylation of alternative splicing factor/splicing factor 2". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 12601–6. doi:10.1073/pnas.1635129100. PMID 14555757.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Hawkins IC, Harvey CD; et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mylonis I, Drosou V, Brancorsini S; et al. (2004). "Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis". J. Biol. Chem. 279 (12): 11626–31. doi:10.1074/jbc.M311949200. PMID 14701833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee CG, Hague LK, Li H, Donnelly R (2004). "Identification of toposome, a novel multisubunit complex containing topoisomerase IIalpha". Cell Cycle. 3 (5): 638–47. PMID 15034300.CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)