PSMB8
| Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | PSMB8 ; D6S216; D6S216E; LMP7; MGC1491; RING10 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 56499 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE PSMB8 209040 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7), also known as PSMB8, is a human gene.[1]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.[1]
References
Further reading
- Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
- Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1". Cell. 114 (3): 281–3. PMID 12914693.
- Früh K, Yang Y, Arnold D; et al. (1992). "Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits". J. Biol. Chem. 267 (31): 22131–40. PMID 1429565.
- Beck S, Kelly A, Radley E; et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. PMID 1453454.
- Bodmer JG, Marsh SG, Albert ED; et al. (1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. PMID 1529427.
- Glynne R, Powis SH, Beck S; et al. (1991). "A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC". Nature. 353 (6342): 357–60. doi:10.1038/353357a0. PMID 1922342.
- Ustrell V, Realini C, Pratt G, Rechsteiner M (1996). "Human lymphoblast and erythrocyte multicatalytic proteases: differential peptidase activities and responses to the 11S regulator". FEBS Lett. 376 (3): 155–8. PMID 7498531.
- Kristensen P, Johnsen AH, Uerkvitz W; et al. (1995). "Human proteasome subunits from 2-dimensional gels identified by partial sequencing". Biochem. Biophys. Res. Commun. 205 (3): 1785–9. PMID 7811265.
- Meinhardt T, Gräf U, Hämmerling GJ (1993). "Different genomic structure of mouse and human Lmp7 genes: characterization of MHC-encoded proteasome genes". Immunogenetics. 38 (5): 373–9. PMID 8344725.
- Glynne R, Kerr LA, Mockridge I; et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–6. PMID 8458375.
- Roby KF, Yang Y, Gershon D, Hunt JS (1996). "Cellular distribution of proteasome subunit Lmp7 mRNA and protein in human placentas". Immunology. 86 (3): 469–74. PMID 8550087.
- Beck S, Abdulla S, Alderton RP; et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
- Hisamatsu H, Shimbara N, Saito Y; et al. (1996). "Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma". J. Exp. Med. 183 (4): 1807–16. PMID 8666937.
- Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8. PMID 9079628.
- Kim TG, Lee YH, Choi HB, Han H (1997). "Two newly discovered alleles of major histocompatibility complex-encoded LMP7 in Korean populations". Hum. Immunol. 46 (1): 61–4. PMID 9157092.
- Vives-Pi M, Vargas F, James RF; et al. (1997). "Proteasome subunits, low-molecular-mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin-dependent diabetes mellitus: implications for autoimmunity". Tissue Antigens. 50 (2): 153–63. PMID 9271825.
- Madani N, Kabat D (1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein". J. Virol. 72 (12): 10251–5. PMID 9811770.
- Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 (12): 1397–400. doi:10.1038/3987. PMID 9846577.
- Sewell AK, Price DA, Teisserenc H; et al. (1999). "IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase". J. Immunol. 162 (12): 7075–9. PMID 10358150.
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