HLA-DRB1

See also: HLA-DR

Major histocompatibility complex, class II, DR beta 1
File:PBB Protein HLA-DRB1 image.jpg PDB rendering based on 1aqd.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1aqd​, 1bx2​, 1d5m​, 1d5x​, 1d5z​, 1d6e​, 1dlh​, 1fv1​, 1fyt​, 1h15​, 1hqr​, 1hxy​, 1j8h​, 1jwm​, 1jws​, 1jwu​, 1kg0​, 1klg​, 1klu​, 1lo5​, 1pyw​, 1r5i​, 1seb​, 1sje​, 1sjh​, 1t5w​, 1t5x​, 1ymm​, 1zgl​, 2fse​, 2g9h​, 2iam​, 2ian​, 2icw​, 2ipk​, 2oje​, 2seb​
Identifiers
Symbols	HLA-DRB1 ; DRB1; HLA DRB1; HLA-DR1B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 85991
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE HLA-DRB1 215193 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Major histocompatibility complex, class II, DR beta 1, also known as HLA-DRB1, is a human gene.

HLA-DRB1 belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Further reading

• Turesson C, Matteson EL (2006). "Genetics of rheumatoid arthritis". Mayo Clin. Proc. 81 (1): 94–101. PMID 16438485.
• Ahmad T, Marshall SE, Jewell D (2006). "Genetics of inflammatory bowel disease: the role of the HLA complex". World J. Gastroenterol. 12 (23): 3628–35. PMID 16773677.CS1 maint: Multiple names: authors list (link)
• Schmidt H, Williamson D, Ashley-Koch A (2007). "HLA-DR15 haplotype and multiple sclerosis: a HuGE review". Am. J. Epidemiol. 165 (10): 1097–109. doi:10.1093/aje/kwk118. PMID 17329717.CS1 maint: Multiple names: authors list (link)