Laminin, beta 1

Laminin, beta 1
Identifiers
Symbols	LAMB1 ; CLM; MGC142015
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1722
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LAMB1 201505 at tn.png
File:PBB GE LAMB1 211651 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Laminin, beta 1, also known as LAMB1, is a human gene.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Further reading

• Ljubimova JY, Fujita M, Khazenzon NM; et al. (2006). "Changes in laminin isoforms associated with brain tumor invasion and angiogenesis". Front. Biosci. 11: 81–8. PMID 16146715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonneau D, Huret JL, Godeau G; et al. (1991). "Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype". Hum. Genet. 87 (3): 317–9. PMID 1864606.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vuolteenaho R, Chow LT, Tryggvason K (1990). "Structure of the human laminin B1 chain gene". J. Biol. Chem. 265 (26): 15611–6. PMID 1975589.CS1 maint: Multiple names: authors list (link)
• Ikonen J, Pikkarainen T, Savolainen ER, Tryggvason K (1989). "A Hpa I polymorphism in the human laminin B1 chain gene on 7q22". Nucleic Acids Res. 17 (1): 473. PMID 2563160.CS1 maint: Multiple names: authors list (link)
• Roche KB, Moore JW, Surana RB, Wilson BE (1989). "Aortic root dilatation associated with partial trisomy 7(q31.2----qter)". Pediatric cardiology. 10 (1): 53–5. PMID 2704655.CS1 maint: Multiple names: authors list (link)
• Sasaki M, Kato S, Kohno K; et al. (1987). "Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats". Proc. Natl. Acad. Sci. U.S.A. 84 (4): 935–9. PMID 3493487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pikkarainen T, Eddy R, Fukushima Y; et al. (1987). "Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7". J. Biol. Chem. 262 (22): 10454–62. PMID 3611077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaye M, Modi WS, Ricca GA; et al. (1987). "Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization". Am. J. Hum. Genet. 41 (4): 605–15. PMID 3661559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burgeson RE, Chiquet M, Deutzmann R; et al. (1994). "A new nomenclature for the laminins". Matrix Biol. 14 (3): 209–11. PMID 7921537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lohi J, Leivo I, Franssila K, Virtanen I (1997). "Changes in the distribution of integrins and their basement membrane ligands during development of human thyroid follicular epithelium". Histochem. J. 29 (4): 337–45. PMID 9184849.CS1 maint: Multiple names: authors list (link)
• Taylor J, Muntoni F, Robb S; et al. (1997). "Early onset autosomal dominant myopathy with rigidity of the spine: a possible role for laminin beta 1?". Neuromuscul. Disord. 7 (4): 211–6. PMID 9196901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sewry CA, D'Alessandro M, Wilson LA; et al. (1997). "Expression of laminin chains in skin in merosin-deficient congenital muscular dystrophy". Neuropediatrics. 28 (4): 217–22. PMID 9309712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mahida YR, Beltinger J, Makh S; et al. (1998). "Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2". Am. J. Physiol. 273 (6 Pt 1): G1341–8. PMID 9435560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Grady P, Thai TC, Saito H (1998). "The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR". J. Cell Biol. 141 (7): 1675–84. PMID 9647658.CS1 maint: Multiple names: authors list (link)
• Koch M, Olson PF, Albus A; et al. (1999). "Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain". J. Cell Biol. 145 (3): 605–18. PMID 10225960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Merlini L, Villanova M, Sabatelli P; et al. (1999). "Decreased expression of laminin beta 1 in chromosome 21-linked Bethlem myopathy". Neuromuscul. Disord. 9 (5): 326–9. PMID 10407855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kikkawa Y, Sanzen N, Fujiwara H; et al. (2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". J. Cell. Sci. 113 ( Pt 5): 869–76. PMID 10671376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirosaki T, Mizushima H, Tsubota Y; et al. (2000). "Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5". J. Biol. Chem. 275 (29): 22495–502. doi:10.1074/jbc.M001326200. PMID 10801807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Champliaud MF, Virtanen I, Tiger CF; et al. (2000). "Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta". Exp. Cell Res. 259 (2): 326–35. doi:10.1006/excr.2000.4980. PMID 10964500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pedraza C, Geberhiwot T, Ingerpuu S; et al. (2000). "Monocytic cells synthesize, adhere to, and migrate on laminin-8 (alpha 4 beta 1 gamma 1)". J. Immunol. 165 (10): 5831–8. PMID 11067943.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)