RHEB

Ras homolog enriched in brain
File:PBB Protein RHEB image.jpg PDB rendering based on 1xtq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1xtq​, 1xtr​, 1xts​
Identifiers
Symbols	RHEB ; MGC111559; RHEB2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4101
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE RHEB 201452 at tn.png
File:PBB GE RHEB 201453 x at tn.png
File:PBB GE RHEB 213404 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ras homolog enriched in brain, also known as RHEB, is a human gene.

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.

Further reading

• Yamagata K, Sanders LK, Kaufmann WE; et al. (1994). "rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein". J. Biol. Chem. 269 (23): 16333–9. PMID 8206940.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gromov PS, Madsen P, Tomerup N, Celis JE (1996). "A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb". FEBS Lett. 377 (2): 221–6. PMID 8543055.CS1 maint: Multiple names: authors list (link)
• Mizuki N, Kimura M, Ohno S; et al. (1996). "Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36". Genomics. 34 (1): 114–8. PMID 8661031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Yee WM, Worley PF (1997). "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals". Mol. Cell. Biol. 17 (2): 921–33. PMID 9001246.
• Clark GJ, Kinch MS, Rogers-Graham K; et al. (1997). "The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation". J. Biol. Chem. 272 (16): 10608–15. PMID 9099708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inohara N, Ding L, Chen S, Núñez G (1997). "harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". EMBO J. 16 (7): 1686–94. doi:10.1093/emboj/16.7.1686. PMID 9130713.CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Kita K, Wu YP, Sugaya S; et al. (2000). "Search for UV-responsive genes in human cells by differential mRNA display: involvement of human ras-related GTP-binding protein, Rheb, in UV susceptibility". Biochem. Biophys. Res. Commun. 274 (3): 859–64. doi:10.1006/bbrc.2000.3220. PMID 10924367.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanzal-Bayer M, Renault L, Roversi P; et al. (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMID 11980706.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Gao X, Saucedo LJ; et al. (2003). "Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins". Nat. Cell Biol. 5 (6): 578–81. doi:10.1038/ncb999. PMID 12771962.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Garami A, Zwartkruis FJ, Nobukuni T; et al. (2003). "Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2". Mol. Cell. 11 (6): 1457–66. PMID 12820960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Castro AF, Rebhun JF, Clark GJ, Quilliam LA (2003). "Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner". J. Biol. Chem. 278 (35): 32493–6. doi:10.1074/jbc.C300226200. PMID 12842888.CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tabancay AP, Gau CL, Machado IM; et al. (2003). "Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K". J. Biol. Chem. 278 (41): 39921–30. doi:10.1074/jbc.M306553200. PMID 12869548.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoki K, Li Y, Xu T, Guan KL (2003). "Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling". Genes Dev. 17 (15): 1829–34. doi:10.1101/gad.1110003. PMID 12869586.CS1 maint: Multiple names: authors list (link)
• Tee AR, Manning BD, Roux PP; et al. (2004). "Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb". Curr. Biol. 13 (15): 1259–68. PMID 12906785.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)