CARD11

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Caspase recruitment domain family, member 11
Identifiers
Symbols CARD11 ; BIMP3; CARMA1; MGC133069
External IDs Template:OMIM5 Template:MGI HomoloGene: 13024
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Caspase recruitment domain family, member 11, also known as CARD11, is a human gene.[1]

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: CARD11 caspase recruitment domain family, member 11".

Further reading

  • Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.
  • "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
  • Wang L, Guo Y, Huang WJ; et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
  • Bertin J, Wang L, Guo Y; et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
  • Gaide O, Martinon F, Micheau O; et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. PMID 11356195.
  • Wang D, You Y, Case SM; et al. (2002). "A requirement for CARMA1 in TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 830–5. doi:10.1038/ni824. PMID 12154356.
  • Gaide O, Favier B, Legler DF; et al. (2002). "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 836–43. doi:10.1038/ni830. PMID 12154360.
  • Pomerantz JL, Denny EM, Baltimore D (2002). "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex". EMBO J. 21 (19): 5184–94. PMID 12356734.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
  • Wang D, Matsumoto R, You Y; et al. (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1". Mol. Cell. Biol. 24 (1): 164–71. PMID 14673152.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Stilo R, Liguoro D, Di Jeso B; et al. (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
  • Lee KY, D'Acquisto F, Hayden MS; et al. (2005). "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science. 308 (5718): 114–8. doi:10.1126/science.1107107. PMID 15802604.
  • Shinohara H, Yasuda T, Aiba Y; et al. (2006). "PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1". J. Exp. Med. 202 (10): 1423–31. doi:10.1084/jem.20051591. PMID 16301747.
  • Sommer K, Guo B, Pomerantz JL; et al. (2006). "Phosphorylation of the CARMA1 linker controls NF-kappaB activation". Immunity. 23 (6): 561–74. doi:10.1016/j.immuni.2005.09.014. PMID 16356855.
  • Matsumoto R, Wang D, Blonska M; et al. (2006). "Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation". Immunity. 23 (6): 575–85. doi:10.1016/j.immuni.2005.10.007. PMID 16356856.
  • Narayan P, Holt B, Tosti R, Kane LP (2006). "CARMA1 is required for Akt-mediated NF-kappaB activation in T cells". Mol. Cell. Biol. 26 (6): 2327–36. doi:10.1128/MCB.26.6.2327-2336.2006. PMID 16508008.
  • Ishiguro K, Avruch J, Landry A; et al. (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMID 16520020.
  • Ishiguro K, Green T, Rapley J; et al. (2006). "Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation". Mol. Cell. Biol. 26 (14): 5497–508. doi:10.1128/MCB.02469-05. PMID 16809782.

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