NT5C3

5'-nucleotidase, cytosolic III
File:PBB Protein NT5C3 image.jpg PDB rendering based on 2bdu.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2bdu​, 2cn1​, 2g06​, 2g07​, 2g08​, 2g09​, 2g0a​, 2jga​
Identifiers
Symbols	NT5C3 ; PN-I; MGC27337; MGC87109; MGC87828; P5'N-1; PSN1; UMPH; UMPH1; cN-III
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9534
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

5'-nucleotidase, cytosolic III, also known as NT5C3, is a human gene.

Pyrimidine 5-prime-nucleotidase (P5N; EC 3.1.3.5), also called uridine 5-prime monophosphate hydrolase (UMPH), catalyzes the dephosphorylation of the pyrimidine 5-prime monophosphates UMP and CMP to the corresponding nucleosides. There are 2 isozymes of pyrimidine 5-prime nucleotidase in red blood cells, referred to as type I (UMPH1) and type II (UMPH2; MIM 191720). The 2 enzymes are not separable by electrophoresis in humans but have distinct kinetic properties, and the proteins show no homology.[supplied by OMIM]

Further reading

• Amici A, Emanuelli M, Ferretti E; et al. (1995). "Homogeneous pyrimidine nucleotidase from human erythrocytes: enzymic and molecular properties". Biochem. J. 304 ( Pt 3): 987–92. PMID 7818506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rich SA, Bose M, Tempst P, Rudofsky UH (1996). "Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions". J. Biol. Chem. 271 (2): 1118–26. PMID 8557639.CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amici A, Emanuelli M, Magni G; et al. (1998). "Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides". FEBS Lett. 419 (2–3): 263–7. PMID 9428647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amici A, Emanuelli M, Raffaelli N; et al. (2000). "Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon". Blood. 96 (4): 1596–8. PMID 10942414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMID 11042152.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marinaki AM, Escuredo E, Duley JA; et al. (2001). "Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency". Blood. 97 (11): 3327–32. PMID 11369620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Amici A, Magni G (2002). "Human erythrocyte pyrimidine 5'-nucleotidase, PN-I". Arch. Biochem. Biophys. 397 (2): 184–90. doi:10.1006/abbi.2001.2676. PMID 11795870.
• Amici A, Emanuelli M, Ruggieri S; et al. (2003). "Kinetic evidence for covalent phosphoryl-enzyme intermediate in phosphotransferase activity of human red cell pyrimidine nucleotidases". Meth. Enzymol. 354: 149–59. PMID 12418222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Balta G, Gumruk F, Akarsu N; et al. (2003). "Molecular characterization of Turkish patients with pyrimidine 5' nucleotidase-I deficiency". Blood. 102 (5): 1900–3. doi:10.1182/blood-2003-02-0628. PMID 12714505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bianchi P, Fermo E, Alfinito F; et al. (2003). "Molecular characterization of six unrelated Italian patients affected by pyrimidine 5'-nucleotidase deficiency". Br. J. Haematol. 122 (5): 847–51. PMID 12930399.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kanno H, Takizawa T, Miwa S, Fujii H (2004). "Molecular basis of Japanese variants of pyrimidine 5'-nucleotidase deficiency". Br. J. Haematol. 126 (2): 265–71. doi:10.1111/j.1365-2141.2004.05029.x. PMID 15238149.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chiarelli LR, Bianchi P, Fermo E; et al. (2005). "Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia". Blood. 105 (8): 3340–5. doi:10.1182/blood-2004-10-3895. PMID 15604219.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)