LRRC4

Leucine rich repeat containing 4
File:PBB Protein LRRC4 image.jpg PDB rendering based on 2dl9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dl9​
Identifiers
Symbols	LRRC4 ; MGC133342; MGC133343; NAG14
External IDs	Template:OMIM5 Template:MGI HomoloGene: 36403
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LRRC4 gnf1h00399 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Leucine rich repeat containing 4, also known as LRRC4, is a human gene.

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Nakashiba T, Ikeda T, Nishimura S; et al. (2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins". J. Neurosci. 20 (17): 6540–50. PMID 10964959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang JR, Li XL, Fan SQ; et al. (2004). "Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251". Ai Zheng. 22 (9): 897–902. PMID 12969517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin JC, Ho WH, Gurney A, Rosenthal A (2004). "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons". Nat. Neurosci. 6 (12): 1270–6. doi:10.1038/nn1148. PMID 14595443.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Q, Wang J, Fan S; et al. (2005). "Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily". FEBS Lett. 579 (17): 3674–82. doi:10.1016/j.febslet.2005.05.058. PMID 15967442.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QH, Wang LL, Cao L; et al. (2005). "Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system". Acta Biochim. Biophys. Sin. (Shanghai). 37 (8): 532–40. PMID 16077900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fan SQ, Wang JR, Huang H; et al. (2007). "[Function of a novel brain-specific gene LRRC4]". Zhonghua Zhong Liu Za Zhi. 27 (7): 393–6. PMID 16188120.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang QH, Wu MH, Wang LL; et al. (2005). "Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array". Acta Biochim. Biophys. Sin. (Shanghai). 37 (10): 680–7. PMID 16215635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu M, Huang C, Gan K; et al. (2006). "LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway". Mol. Biol. Cell. 17 (8): 3534–42. doi:10.1091/mbc.E05-11-1082. PMID 16723503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu M, Gan K, Huang C; et al. (2007). "LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression". J. Neurooncol. 80 (2): 133–42. doi:10.1007/s11060-006-9173-6. PMID 16941076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu M, Huang C, Li X; et al. (2007). "LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses". J. Cell. Physiol. 214 (1): 65–74. doi:10.1002/jcp.21163. PMID 17541939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)