CCT6A

Chaperonin containing TCP1, subunit 6A (zeta 1)
Identifiers
Symbols	CCT6A ; CCT-zeta; CCT-zeta-1; CCT6; Cctz; HTR3; MGC126214; MGC126215; MoDP-2; TCP-1-zeta; TCP20; TCPZ; TTCP20
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1336
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Chaperonin containing TCP1, subunit 6A (zeta 1), also known as CCT6A, is a human gene.

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Further reading

• Segel GB, Boal TR, Cardillo TS; et al. (1992). "Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 6060–4. PMID 1352881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Kubota H, Hynes G, Carne A; et al. (1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Curr. Biol. 4 (2): 89–99. PMID 7953530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li WZ, Lin P, Frydman J; et al. (1994). "Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast". J. Biol. Chem. 269 (28): 18616–22. PMID 8034610.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwartz GJ, Kittelberger AM, Segel GB (2000). "Cloning of rabbit Cct6 and the distribution of the Cct complex in mammalian tissues". Exp. Nephrol. 8 (3): 152–60. PMID 10810232.CS1 maint: Multiple names: authors list (link)
• Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. PMID 11532003.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imai Y, Soda M, Murakami T; et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Higo M, Uzawa K, Kouzu Y; et al. (2005). "Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using DNA microarrays". Oncol. Rep. 14 (5): 1293–8. PMID 16211299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guo D, Han J, Adam BL; et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)