XRCC2
| X-ray repair complementing defective repair in Chinese hamster cells 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | XRCC2 ; DKFZp781P0919 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3964 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE XRCC2 207598 x at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
X-ray repair complementing defective repair in Chinese hamster cells 2, also known as XRCC2, is a human gene.[1]
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.[1]
References
Further reading
- Jones NJ, Zhao Y, Siciliano MJ, Thompson LH (1995). "Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis". Genomics. 26 (3): 619–22. PMID 7607692.
- Thacker J, Tambini CE, Simpson PJ; et al. (1995). "Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents". Hum. Mol. Genet. 4 (1): 113–20. PMID 7711722.
- Tambini CE, George AM, Rommens JM; et al. (1997). "The XRCC2 DNA repair gene: identification of a positional candidate". Genomics. 41 (1): 84–92. doi:10.1006/geno.1997.4636. PMID 9126486.
- Cartwright R, Tambini CE, Simpson PJ, Thacker J (1998). "The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family". Nucleic Acids Res. 26 (13): 3084–9. PMID 9628903.
- Liu N, Lamerdin JE, Tebbs RS; et al. (1998). "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages". Mol. Cell. 1 (6): 783–93. PMID 9660962.
- Cui X, Brenneman M, Meyne J; et al. (1999). "The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells". Mutat. Res. 434 (2): 75–88. PMID 10422536.
- Johnson RD, Liu N, Jasin M (1999). "Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination". Nature. 401 (6751): 397–9. doi:10.1038/43932. PMID 10517641.
- Schild D, Lio YC, Collins DW; et al. (2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
- Braybrooke JP, Spink KG, Thacker J, Hickson ID (2000). "The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2". J. Biol. Chem. 275 (37): 29100–6. doi:10.1074/jbc.M002075200. PMID 10871607.
- O'Regan P, Wilson C, Townsend S, Thacker J (2001). "XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding". J. Biol. Chem. 276 (25): 22148–53. doi:10.1074/jbc.M102396200. PMID 11301337.
- Miller KA, Yoshikawa DM, McConnell IR; et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
- Masson JY, Tarsounas MC, Stasiak AZ; et al. (2002). "Identification and purification of two distinct complexes containing the five RAD51 paralogs". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMID 11751635.
- Kurumizaka H, Ikawa S, Nakada M; et al. (2002). "Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex". J. Biol. Chem. 277 (16): 14315–20. doi:10.1074/jbc.M105719200. PMID 11834724.
- Wiese C, Collins DW, Albala JS; et al. (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells". Nucleic Acids Res. 30 (4): 1001–8. PMID 11842112.
- Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. PMID 11842113.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Braybrooke JP, Li JL, Wu L; et al. (2004). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. PMID 12975363.
- Mohindra A, Bolderson E, Stone J; et al. (2004). "A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks". Hum. Mol. Genet. 13 (2): 203–12. doi:10.1093/hmg/ddh022. PMID 14645207.
- Tarsounas M, Davies AA, West SC (2004). "RAD51 localization and activation following DNA damage". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 359 (1441): 87–93. doi:10.1098/rstb.2003.1368. PMID 15065660.
- Hussain S, Wilson JB, Medhurst AL; et al. (2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.
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