NRCAM

Neuronal cell adhesion molecule
File:PBB Protein NRCAM image.jpg PDB rendering based on 1uen.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1uen​, 1uey​
Identifiers
Symbols	NRCAM ; KIAA0343; MGC138845; MGC138846
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21041
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NRCAM 204105 s at tn.png
File:PBB GE NRCAM 216959 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Neuronal cell adhesion molecule, also known as NRCAM, is a human gene.

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and receptor functions". Cell Tissue Res. 290 (2): 423–8. PMID 9321706.
• Lane RP, Chen XN, Yamakawa K; et al. (1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. 35 (3): 456–65. doi:10.1006/geno.1996.0385. PMID 8812479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakurai T, Lustig M, Nativ M; et al. (1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". J. Cell Biol. 136 (4): 907–18. PMID 9049255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang B, Williams H, Du JS; et al. (1998). "Alternative splicing of human NrCAM in neural and nonneural tissues". Mol. Cell. Neurosci. 10 (5–6): 287–95. doi:10.1006/mcne.1997.0658. PMID 9604207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moré MI, Kirsch FP, Rathjen FG (2001). "Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation". J. Cell Biol. 154 (1): 187–96. PMID 11449000.CS1 maint: Multiple names: authors list (link)
• Dry K, Kenwrick S, Rosenthal A, Platzer M (2001). "The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily". Gene. 273 (1): 115–22. PMID 11483367.CS1 maint: Multiple names: authors list (link)
• Jenkins SM, Bennett V (2002). "Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments". J. Cell Biol. 155 (5): 739–46. doi:10.1083/jcb.200109026. PMID 11724816.
• Aitkenhead M, Wang SJ, Nakatsu MN; et al. (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM". Microvasc. Res. 63 (2): 159–71. doi:10.1006/mvre.2001.2380. PMID 11866539.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pavlou O, Theodorakis K, Falk J; et al. (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Mol. Cell. Neurosci. 20 (3): 367–81. PMID 12139915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conacci-Sorrell ME, Ben-Yedidia T, Shtutman M; et al. (2002). "Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis". Genes Dev. 16 (16): 2058–72. doi:10.1101/gad.227502. PMID 12183361.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Custer AW, Kazarinova-Noyes K, Sakurai T; et al. (2003). "The role of the ankyrin-binding protein NrCAM in node of Ranvier formation". J. Neurosci. 23 (31): 10032–9. PMID 14602817.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hutcheson HB, Olson LM, Bradford Y; et al. (2004). "Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes". BMC Med. Genet. 5: 12. doi:10.1186/1471-2350-5-12. PMID 15128462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonora E, Lamb JA, Barnby G; et al. (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi:10.1038/sj.ejhg.5201315. PMID 15523497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishiguro H, Liu QR, Gong JP; et al. (2006). "NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice". Neuropsychopharmacology. 31 (3): 572–84. doi:10.1038/sj.npp.1300855. PMID 16123759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)