Glutathione reductase
| Glutathione reductase | |
|---|---|
| File:Glutathione reductase.png | |
| Identifiers | |
| Symbol | GSR |
| Entrez | 2936 |
| HUGO | 4623 |
| OMIM | 138300 |
| RefSeq | NM_000637 |
| UniProt | P00390 |
| Other data | |
| EC number | 1.8.1.7 |
| Locus | Chr. 8 p21.1 |
Glutathione reductase is an enzyme (EC 1.8.1.7) which reduces glutathione disulphide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant.[1][2][3]
For every mole of GSSG one mole of NADPH is required.
In cells exposed to high levels of oxidative stress, like red blood cells, up to 10% of the glucose consumption may be used for production of the NADPH needed for this reaction.
References
- ↑ Meister A, Anderson M. "Glutathione". Annu Rev Biochem. 52: 711–60. PMID 6137189.
- ↑ Meister A (1988). "Glutathione metabolism and its selective modification" (PDF). J Biol Chem. 263 (33): 17205–8. PMID 3053703.
- ↑ Mannervik B (1987). "The enzymes of glutathione metabolism: an overview". Biochem. Soc. Trans. 15 (4): 717–8. PMID 3315772.