STC1
| Stanniocalcin 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | STC1 ; STC | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2374 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE STC1 204595 s at tn.png | |||||||||||
| File:PBB GE STC1 204596 s at tn.png | |||||||||||
| File:PBB GE STC1 204597 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Stanniocalcin 1, also known as STC1, is a human gene.[1]
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.[1]
References
Further reading
- Chang AC, Jellinek DA, Reddel RR (2004). "Mammalian stanniocalcins and cancer". Endocr. Relat. Cancer. 10 (3): 359–73. PMID 14503913.
- Liang P, Averboukh L, Keyomarsi K; et al. (1993). "Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells". Cancer Res. 52 (24): 6966–8. PMID 1458489.
- Chang AC, Janosi J, Hulsbeek M; et al. (1996). "A novel human cDNA highly homologous to the fish hormone stanniocalcin". Mol. Cell. Endocrinol. 112 (2): 241–7. PMID 7489828.
- Wagner GF, Guiraudon CC, Milliken C, Copp DH (1995). "Immunological and biological evidence for a stanniocalcin-like hormone in human kidney". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 1871–5. PMID 7892193.
- Olsen HS, Cepeda MA, Zhang QQ; et al. (1996). "Human stanniocalcin: a possible hormonal regulator of mineral metabolism". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 1792–6. PMID 8700837.
- Chang AC, Jeffrey KJ, Tokutake Y; et al. (1998). "Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats". Genomics. 47 (3): 393–8. doi:10.1006/geno.1997.5120. PMID 9480753.
- Zhang KZ, Westberg JA, Paetau A; et al. (1998). "High expression of stanniocalcin in differentiated brain neurons". Am. J. Pathol. 153 (2): 439–45. PMID 9708804.
- Varghese R, Wong CK, Deol H; et al. (1998). "Comparative analysis of mammalian stanniocalcin genes". Endocrinology. 139 (11): 4714–25. PMID 9794484.
- Zhang K, Lindsberg PJ, Tatlisumak T; et al. (2000). "Stanniocalcin: A molecular guard of neurons during cerebral ischemia". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3637–42. doi:10.1073/pnas.070045897. PMID 10725397.
- Jellinek DA, Chang AC, Larsen MR; et al. (2001). "Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells". Biochem. J. 350 Pt 2: 453–61. PMID 10947959.
- Varghese R, Gagliardi AD, Bialek PE; et al. (2002). "Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice". Endocrinology. 143 (3): 868–76. PMID 11861508.
- McCudden CR, James KA, Hasilo C, Wagner GF (2003). "Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism". J. Biol. Chem. 277 (47): 45249–58. doi:10.1074/jbc.M205954200. PMID 12223480.
- Serlachius M, Alitalo R, Olsen HS, Andersson LC (2002). "Expression of stanniocalcin-1 in megakaryocytes and platelets". Br. J. Haematol. 119 (2): 359–63. PMID 12406069.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Sheikh-Hamad D, Bick R, Wu GY; et al. (2003). "Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure". Am. J. Physiol. Heart Circ. Physiol. 285 (1): H442–8. doi:10.1152/ajpheart.01071.2002. PMID 12663264.
- Zlot C, Ingle G, Hongo J; et al. (2004). "Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor". J. Biol. Chem. 278 (48): 47654–9. doi:10.1074/jbc.M301353200. PMID 14500721.
- McCudden CR, Majewski A, Chakrabarti S, Wagner GF (2004). "Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas". Mol. Cell. Endocrinol. 213 (2): 167–72. doi:10.1016/j.mce.2003.10.042. PMID 15062564.
- Luo CW, Kawamura K, Klein C, Hsueh AJ (2005). "Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors". Mol. Endocrinol. 18 (8): 2085–96. doi:10.1210/me.2004-0066. PMID 15131261.
- Serlachius M, Andersson LC (2004). "Upregulated expression of stanniocalcin-1 during adipogenesis". Exp. Cell Res. 296 (2): 256–64. doi:10.1016/j.yexcr.2004.02.016. PMID 15149855.
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