TERF1

Telomeric repeat binding factor (NIMA-interacting) 1
File:PBB Protein TERF1 image.jpg PDB rendering based on 1ba5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ba5​, 1h6o​, 1ity​, 1iv6​, 1w0t​
Identifiers
Symbols	TERF1 ; TRF; FLJ41416; PIN2; TRBF1; TRF1; hTRF1-AS; t-TRF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7570
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Telomeric repeat binding factor (NIMA-interacting) 1, also known as TERF1, is a human gene.

This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.

Further reading

• Zhong Z, Shiue L, Kaplan S, de Lange T (1992). "A mammalian factor that binds telomeric TTAGGG repeats in vitro". Mol. Cell. Biol. 12 (11): 4834–43. PMID 1406665.CS1 maint: Multiple names: authors list (link)
• Chong L, van Steensel B, Broccoli D; et al. (1996). "A human telomeric protein". Science. 270 (5242): 1663–7. PMID 7502076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu KP, Hanes SD, Hunter T (1996). "A human peptidyl-prolyl isomerase essential for regulation of mitosis". Nature. 380 (6574): 544–7. doi:10.1038/380544a0. PMID 8606777.CS1 maint: Multiple names: authors list (link)
• Bilaud T, Koering CE, Binet-Brasselet E; et al. (1996). "The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human". Nucleic Acids Res. 24 (7): 1294–303. PMID 8614633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Broccoli D, Chong L, Oelmann S; et al. (1997). "Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains". Hum. Mol. Genet. 6 (1): 69–76. PMID 9002672.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bianchi A, Smith S, Chong L; et al. (1997). "TRF1 is a dimer and bends telomeric DNA". EMBO J. 16 (7): 1785–94. doi:10.1093/emboj/16.7.1785. PMID 9130722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Broccoli D, Smogorzewska A, Chong L, de Lange T (1997). "Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2". Nat. Genet. 17 (2): 231–5. doi:10.1038/ng1097-231. PMID 9326950.CS1 maint: Multiple names: authors list (link)
• Shen M, Haggblom C, Vogt M; et al. (1998). "Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13618–23. PMID 9391075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nosaka K, Kawahara M, Masuda M; et al. (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishikawa T, Nagadoi A, Yoshimura S; et al. (1998). "Solution structure of the DNA-binding domain of human telomeric protein, hTRF1". Structure. 6 (8): 1057–65. PMID 9739097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith S, Giriat I, Schmitt A, de Lange T (1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science. 282 (5393): 1484–7. PMID 9822378.CS1 maint: Multiple names: authors list (link)
• Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMID 10581025.CS1 maint: Multiple names: authors list (link)
• Smogorzewska A, van Steensel B, Bianchi A; et al. (2000). "Control of human telomere length by TRF1 and TRF2". Mol. Cell. Biol. 20 (5): 1659–68. PMID 10669743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu G, Lee WH, Chen PL (2000). "NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres". J. Biol. Chem. 275 (39): 30618–22. doi:10.1074/jbc.C000390200. PMID 10913111.CS1 maint: Multiple names: authors list (link)
• Chi NW, Lodish HF (2001). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. 275 (49): 38437–44. doi:10.1074/jbc.M007635200. PMID 10988299.
• Kishi S, Wulf G, Nakamura M, Lu KP (2001). "Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors". Oncogene. 20 (12): 1497–508. doi:10.1038/sj.onc.1204229. PMID 11313893.CS1 maint: Multiple names: authors list (link)
• Kishi S, Zhou XZ, Ziv Y; et al. (2001). "Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks". J. Biol. Chem. 276 (31): 29282–91. doi:10.1074/jbc.M011534200. PMID 11375976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fairall L, Chapman L, Moss H; et al. (2001). "Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2". Mol. Cell. 8 (2): 351–61. PMID 11545737.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou XZ, Lu KP (2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell. 107 (3): 347–59. PMID 11701125.
• Nishikawa T, Okamura H, Nagadoi A; et al. (2002). "Solution structure of a telomeric DNA complex of human TRF1". Structure. 9 (12): 1237–51. PMID 11738049.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)