UBE2V2

Ubiquitin-conjugating enzyme E2 variant 2
File:PBB Protein UBE2V2 image.jpg PDB rendering based on 1j74.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1j74​, 1j7d​, 1zgu​, 2a4d​, 2c2v​, 2hlw​
Identifiers
Symbols	UBE2V2 ; DDVIT1; DDVit-1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55739
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UBE2V2 209096 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin-conjugating enzyme E2 variant 2, also known as UBE2V2, is a human gene.

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.

Further reading

• Fritsche J, Rehli M, Krause SW; et al. (1997). "Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes". Biochem. Biophys. Res. Commun. 235 (2): 407–12. PMID 9199207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sancho E, Vilá MR, Sánchez-Pulido L; et al. (1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol. Cell. Biol. 18 (1): 576–89. PMID 9418904.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao W, Lin SL, Broomfield S; et al. (1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family". Nucleic Acids Res. 26 (17): 3908–14. PMID 9705497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hofmann RM, Pickart CM (1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair". Cell. 96 (5): 645–53. PMID 10089880.
• Chan NL, Hill CP (2001). "Defining polyubiquitin chain topology". Nat. Struct. Biol. 8 (8): 650–2. doi:10.1038/90337. PMID 11473244.
• Moraes TF, Edwards RA, McKenna S; et al. (2001). "Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13". Nat. Struct. Biol. 8 (8): 669–73. doi:10.1038/90373. PMID 11473255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bothos J, Summers MK, Venere M; et al. (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains". Oncogene. 22 (46): 7101–7. doi:10.1038/sj.onc.1206831. PMID 14562038.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou H, Wertz I, O'Rourke K; et al. (2004). "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO". Nature. 427 (6970): 167–71. doi:10.1038/nature02273. PMID 14695475.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Simpson LJ, Sale JE (2005). "UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40". DNA Repair (Amst.). 4 (4): 503–10. doi:10.1016/j.dnarep.2004.12.002. PMID 15725630.
• Pastushok L, Moraes TF, Ellison MJ, Xiao W (2005). "A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex". J. Biol. Chem. 280 (18): 17891–900. doi:10.1074/jbc.M410469200. PMID 15749714.CS1 maint: Multiple names: authors list (link)
• Spyracopoulos L, Lewis MJ, Saltibus LF (2005). "Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States". Biochemistry. 44 (24): 8770–81. doi:10.1021/bi050065k. PMID 15952783.CS1 maint: Multiple names: authors list (link)
• Andersen PL, Zhou H, Pastushok L; et al. (2005). "Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A". J. Cell Biol. 170 (5): 745–55. doi:10.1083/jcb.200502113. PMID 16129784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wen R, Newton L, Li G; et al. (2006). "Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants". Plant Mol. Biol. 61 (1–2): 241–53. doi:10.1007/s11103-006-0007-x. PMID 16786304.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao GY, Sonoda E, Barber LJ; et al. (2007). "A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination". Mol. Cell. 25 (5): 663–75. doi:10.1016/j.molcel.2007.01.029. PMID 17349954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)