BNIP3L

BCL2/adenovirus E1B 19kDa interacting protein 3-like
Identifiers
Symbols	BNIP3L ; BNIP3a; NIX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3195
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

BCL2/adenovirus E1B 19kDa interacting protein 3-like, also known as BNIP3L, is a human gene.

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.

Further reading

• Matsushima M, Fujiwara T, Takahashi E; et al. (1998). "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3". Genes Chromosomes Cancer. 21 (3): 230–5. PMID 9523198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen G, Cizeau J, Vande Velde C; et al. (1999). "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins". J. Biol. Chem. 274 (1): 7–10. PMID 9867803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yasuda M, Han JW, Dionne CA; et al. (1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Res. 59 (3): 533–7. PMID 9973195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohi N, Tokunaga A, Tsunoda H; et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imazu T, Shimizu S, Tagami S; et al. (1999). "Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability". Oncogene. 18 (32): 4523–9. doi:10.1038/sj.onc.1202722. PMID 10467396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Passer BJ, Nancy-Portebois V, Amzallag N; et al. (2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMID 12606722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aerbajinai W, Giattina M, Lee YT; et al. (2003). "The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation". Blood. 102 (2): 712–7. doi:10.1182/blood-2002-11-3324. PMID 12663450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sun JL, He XS, Yu YH, Chen ZC (2004). "[Expression and structure of BNIP3L in lung cancer]". Ai Zheng. 23 (1): 8–14. PMID 14720367.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fei P, Wang W, Kim SH; et al. (2005). "Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth". Cancer Cell. 6 (6): 597–609. doi:10.1016/j.ccr.2004.10.012. PMID 15607964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stepan H, Leo C, Purz S; et al. (2006). "Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome". Eur. J. Obstet. Gynecol. Reprod. Biol. 122 (2): 172–6. doi:10.1016/j.ejogrb.2005.01.017. PMID 16219518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)