DLGAP2

Discs, large (Drosophila) homolog-associated protein 2
Identifiers
Symbols	DLGAP2 ; DAP2; SAPAP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3484
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Discs, large (Drosophila) homolog-associated protein 2, also known as DLGAP2, is a human gene.

The product of this gene is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. These kinases are a family of signaling molecules expressed at various submembrane domains and contain the PDZ, SH3 and the guanylate kinase domains. This protein may play a role in the molecular organization of synapses and in neuronal cell signaling. Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length nature is not known.

Further reading

• Takeuchi M, Hata Y, Hirao K; et al. (1997). "SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density". J. Biol. Chem. 272 (18): 11943–51. PMID 9115257.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naisbitt S, Kim E, Weinberg RJ; et al. (1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90". J. Neurosci. 17 (15): 5687–96. PMID 9221768.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Satoh K, Yanai H, Senda T; et al. (1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes Cells. 2 (6): 415–24. PMID 9286858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ranta S, Lehesjoki AE, de Fatima Bonaldo M; et al. (1997). "High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p". Genome Res. 7 (9): 887–96. PMID 9314494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirao K, Hata Y, Ide N; et al. (1998). "A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins". J. Biol. Chem. 273 (33): 21105–10. PMID 9694864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawabe H, Hata Y, Takeuchi M; et al. (1999). "nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP)". J. Biol. Chem. 274 (43): 30914–8. PMID 10521485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirao K, Hata Y, Deguchi M; et al. (2000). "Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments". Genes Cells. 5 (3): 203–10. PMID 10759891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang P, Zhang Q, Tochio H; et al. (2000). "Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution". Eur. J. Biochem. 267 (11): 3116–22. PMID 10824095.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ranta S, Zhang Y, Ross B; et al. (2000). "Positional cloning and characterisation of the human DLGAP2 gene and its exclusion in progressive epilepsy with mental retardation". Eur. J. Hum. Genet. 8 (5): 381–4. doi:10.1038/sj.ejhg.5200440. PMID 10854099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bolliger MF, Frei K, Winterhalter KH, Gloor SM (2001). "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression". Biochem. J. 356 (Pt 2): 581–8. PMID 11368788.CS1 maint: Multiple names: authors list (link)
• Hu LA, Chen W, Premont RT; et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohtakara K, Nishizawa M, Izawa I; et al. (2003). "Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1". Genes Cells. 7 (11): 1149–60. PMID 12390249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verhoeven K, De Jonghe P, Van de Putte T; et al. (2003). "Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10". Am. J. Hum. Genet. 73 (4): 926–32. doi:10.1086/378159. PMID 14508709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ying Z, Bingaman W, Najm IM (2004). "Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasia". Epilepsia. 45 (4): 314–21. doi:10.1111/j.0013-9580.2004.37703.x. PMID 15030493.CS1 maint: Multiple names: authors list (link)